Narcolepsy: Comorbidities, complexities and future directions - 12/10/22

Doi : 10.1016/j.smrv.2022.101669

Sajni Gudka ^a, Emma Haynes ^b, Joanne Scotney ^c, Sutapa Mukherjee ^d, Simon Frenkel ^e, Sheila Sivam ^f, John Swieca ^g, Ksenia Chamula ^h, David Cunnington ⁱ, Bandana Saini ^f,^j,^⁎
^a Urban Impact Project and Adjunct Senior Research Fellow, School of Population and Global Health, University of Western Australia, Perth, WA, Australia
^b Urban Impact Project and Research Fellow, School of Population and Global Health, University of Western Australia, Perth, WA, Australia
^c Urban Impact Project, Perth, WA, Australia
^d Respiratory and Sleep Medicine, Adelaide Institute for Sleep Health, College of Medicine and Public Health, Flinders University and Respiratory and Sleep Services, Southern Adelaide Local Health Network, SA Health, Adelaide, SA, Australia
^e Western Health, Melbourne, VIC, Australia
^f Woolcock Institute of Medical Research, Royal Prince Alfred Hospital, University of Sydney, Sydney, NSW, Australia
^g Sleep Doctors Australia, Melbourne Sleep Disorders Centre, VIC, Australia
^h Sleep Doctors Australia, VIC, Australia
ⁱ Melbourne Sleep Disorders Centre, VIC, Australia
^j University of Sydney School of Pharmacy, Faculty of Medicine and Health, The University of Sydney, Woolcock Institute of Medical Research, Sydney, NSW, Australia

^∗Corresponding author.

Abstract

Patients with narcolepsy live with a lifelong sleep-wake disorder, impairing their quality of life, productivity, educational and employment outcomes. Clinicians are becoming aware that a significant aspect of the burden of this disease relates to frequent comorbid conditions, including aspects of the patient's emotional, metabolic, sleep and immune health. This review explores the literature describing the comorbidities seen in patients with narcolepsy, to enhance understanding of these often complex presentations. It hopes to encourage a multidisciplinary approach, to collaborate with patients and a broad clinical team, and to maximise clinical and quality of life outcomes, for those living with narcolepsy.

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Keywords : Cataplexy, Chronic disease, Comorbidity, Hypersomnia, Literature review, Multidisciplinary, Narcolepsy, Sleep disorders

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Synthesis and reporting of results

Results

Study selection

Characteristics of included studies

Diagnostic criteria for narcolepsy

Comorbidities in people with narcolepsy

Difference in prevalence of comorbidities by narcolepsy sub-type NT1, NT2 and IH

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Vol 65

Articolo 101669- ottobre 2022 Ritorno al numero

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Narcolepsy: Comorbidities, complexities and future directions - 12/10/22

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