Single-session transarterial chemoembolization combined with percutaneous thermal ablation in liver metastases 3 cm or larger - 03/11/22
, Lambros Tselikas a, b, Frédéric Deschamps a, b, Charles Roux a, Alexandre Delpla a, Eloi Varin a, Antoine Hakime c, Thierry De Baère a, b
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Highlights |
• | Liver metastases 3 cm or larger can be treated percutaneously during a single session using a combination of transarterial chemoembolization and thermal ablation. |
• | A combination of transarterial chemoembolization and thermal ablation is safe. |
• | High local liver metastasis control rates can be achieved by a combined treatment strategy. |
Abstract |
Purpose |
The purpose of this study was to evaluate the safety and efficacy of transarterial chemoembolization (TACE) combined with percutaneous thermal ablation in patients with liver metastases 3 cm in diameter or larger.
Materials and methods |
This retrospective study included 39 patients with a total of 46 liver metastases treated. There were 14 men and 25 women, with a mean age of 55 ± 13.3 (SD) (age range: 28–77 years). All patients were treated with a combination of TACE and thermal ablation in a single session. Primary outcome was local tumor progression. Secondary outcomes were procedure related complications and systemic disease progression.
Results |
Mean tumor size was 3.6 ± 0.6 (SD) cm (range: 3–5 cm). Conventional TACE was performed in 32 liver metastases (32/46; 70%) and drug-eluting beads-TACE in 14 liver metastases (14/46; 30%) followed by radiofrequency ablation in 34 (34/46; 74%), microwave ablation in 11 (11/46; 24%) and cryoablation in one (1/46; 2%) metastasis. Four grade 2 (4/39; 10%) complications were observed. After a mean follow up of 31.9 ± 26.1 (SD) months (range: 2–113 months) overall local tumor progression rate was 15% (7/46). Local tumor progression rate at 12 months was 13% (6/46). Overall systemic disease progression was seen in 29 patients (29/39; 74%) with a systemic disease progression rate at 12 months of 59% (23/39).
Conclusion |
Treatment of large liver metastases with TACE and thermal ablation in a single session is safe and achieves high local control rate.
Il testo completo di questo articolo è disponibile in PDF.Key words : Interventional radiology, Liver metastases, Microwave ablation, Radiofrequency ablation, Transarterial chemoembolization
Abbreviations : AE, CT, cTACE, DEB-TACE, HCC, IQR, IRE, MRI, MWA, RFA, SD, TACE, TAE
Mappa
Vol 103 - N° 11
P. 516-523 - novembre 2022 Ritorno al numero
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