Efficacy of empiric macrolides versus fluoroquinolones in community-acquired pneumonia associated with atypical bacteria: A meta-analysis - 29/11/22
Abstract |
Introduction |
It is unclear if one empiric regimen for community-acquired pneumonia (CAP) associated with atypical bacteria is superior to another. The objective of this meta-analysis was to compare fluoroquinolones to macrolides in the rates of clinical failure in CAP associated with atypical pathogens.
Methods |
We searched PubMed and EMBASE databases for randomized controlled trials (RCTs) comparing the clinical efficacy of fluoroquinolones with macrolides for CAP associated with atypical bacteria. We estimated risk differences (RRs) with 95% confidence intervals (CIs) using random-effects models and assessed for heterogeneity (I2).
Results |
Five RCTs met the inclusion criteria. No significant differences between macrolides and fluoroquinolones and were identified in rates of clinical failure in CAP associated with any atypical bacteria (RR = 1.57 [95% CI 0.73 to 3.38]; p = 0.251; I2 = 0%), Chlamydia pneumoniae (RR = 2.12 [95% CI 0.63 to 7.14]; p = 0.223; I2 = 0%), Mycoplasma pneumoniae (RR = 1.28 [95% CI 0.57 to 2.92]; p = 0.550; I2 = 0%), or Legionella pneumophila (RR = 0.24 [95% CI 0.02 to 2.86]; p = 0.256; I2 = 0%).
Conclusions |
This meta-analysis of RCTs found no significant differences between macrolides and fluoroquinolones in rates of clinical failure in CAP associated with atypical bacteria.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Fluoroquinolone, Macrolide, Pneumonia, Atypical bacteria
Mappa
Vol 82
Articolo 100931- novembre 2022 Ritorno al numero
Articolo precedente
- Mid-term pulmonary sequelae after hospitalisation for COVID-19: The French SISCOVID cohort
- George Calcaianu, Samuel Degoul, Bénédicte Michau, Thibault Payen, Anthony Gschwend, Mathieu Fore, Carmen Iamandi, Hugues Morel, Jean-Philippe Oster, Acya Bizieux, Cécilia Nocent-Ejnaini, Cécile Carvallo, Stéphanie Romanet, François Goupil, Amélie Leurs, Marie-Germaine Legrand, Laurent Portel, Johanna Claustre, Mihaela Calcaianu, Didier Bresson, Didier Debieuvre
- Trans-arterial embolization for hemoptysis in lung transplant recipients
- Guillaume Gravel, Edouard Sage, Elise Cuquemelle, Alexandre Roussel, Antoine Roux, Matthieu Glorion, François Parquin, François Mellot, Clément Picard
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?