Humulus lupus extract rich in xanthohumol improves the clinical course in critically ill COVID-19 patients - 13/01/23
, Mariusz Gagos b, Dorota Siwicka-Gieroba a, Mariusz Piechota c, Jan Siwiec d, Magdalena Bielacz a, Katarzyna Kotfis e, Andrzej Stepulak f, Luiza Grzycka-Kowalczyk h, Andrzej Jaroszynski g, Manu LNG Malbrain a
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Abstract |
Background |
The systemic inflammatory response following severe COVID-19 is associated with poor outcomes. Several anti-inflammatory medications have been studied in COVID-19 patients. Xanthohumol (Xn), a natural extract from hop cones, possesses strong anti-inflammatory and antioxidative properties. The aim of this study was to analyze the effect of Xn on the inflammatory response and the clinical outcome of COVID-19 patients.
Methods |
Adult patients treated for acute respiratory failure (PaO2/FiO2 less than 150) were studied. Patients were randomized into two groups: Xn – patients receiving adjuvant treatment with Xn at a daily dose of 4.5 mg/kg body weight for 7 days, and C – controls. Observations were performed at four time points: immediately after admission to the ICU and on the 3rd, 5th, and 7th days of treatment. The inflammatory response was assessed based on the plasma IL-6 concentration, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), C-reactive protein (CRP) and D-dimer levels. The mortality rate was determined 28 days after admission to the ICU.
Results |
Seventy-two patients were eligible for the study, and 50 were included in the final analysis. The mortality rate was significantly lower and the clinical course was shorter in the Xn group than in the control group (20% vs. 48%, p < 0.05, and 9 ± 3 days vs. 22 ± 8 days, p < 0.001). Treatment with Xn decreased the plasma IL-6 concentration (p < 0.01), D-dimer levels (p < 0.05) and NLR (p < 0.01) more significantly than standard treatment alone.
Conclusion |
Adjuvant therapy with Xn appears to be a promising anti-inflammatory treatment in COVID-19 patients.
Il testo completo di questo articolo è disponibile in PDF.Graphical Abstract |
Highlights |
• | Xanthohumol presents anti-inflammatory properties and decreases the inflammatory response following coronavirus infection. |
• | Xanthohumol improves the clinical course and oxygenation index (PaO2/FiO2) in critically ill COVID-19 patients. |
• | Xanthohumol can be used as an adjuvant therapy to reduce the severity of inflammation in critically ill COVID-19 patients. |
Abbreviations : ACE-2, APACHE II, APTT, CoV-2, CI, CO, CRP, CT, DGAT, FXR, HMGB1, HR, ICU, iNOS, IXn, MAP, NADPH, NLR, ORI, PLR, PRRSV, ROS, SAPS, SARS-CoV-2, SOFA, SpO2, SrO2, SVV, WBC, Xn
Keywords : Xanthohumol, COVID-19, Coronavirus, Critically ill, Inflammatory response, Neutrophil-to-lymphocyte ratio, Mortality
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Vol 158
Articolo 114082- febbraio 2023 Ritorno al numero
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