Implication des organismes de recherche - 30/04/08

Doi : RMR-04-2005-22-2-C3-0761-8425-101019-200504086

M. Aubier
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^[1] Membre du Conseil de réflexion stratégique de l’Inserm (CORES) Inserm U700, Faculté Xavier Bichat, Paris, service de pneumologie, Hôpital Bichat, Paris.

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La recherche sur l’asthme à l’Inserm : un bilan plutôt positif

Six formations Inserm travaillent sur la thématique asthme/allergie

En épidémiologie ^[]^{[2Bouzigon E, Chaudru V, Carpentier AS, Dizier MH, Oryszczyn MP, Maccario J, Kauffmann F, Demenais F : Familial correlations and inter-relationships of four asthma-associated quantitative phenotypes in 320 French EGEA families ascertained through asthmatic probands. Eur J Hum Genet 2004 ; 12 : 955-63.

Cliccare qui per andare alla sezione Riferimenti]}^{[3Leynaert B, Neukirch C, Kony S, Guenegou A, Bousquet J, Aubier M, Neukirch F : Association between asthma and rhinitis according to atopic sensitization in a population-based study. J Allergy Clin Immunol 2004 ; 113 : 86-93.

Cliccare qui per andare alla sezione Riferimenti]}^{[4Zureik M, Neukirch C, Leynaert B, Liard R, Bousquet J, Neukirch F. European Community Respiratory Health Survey : Sensitisation to airborne moulds and severity of asthma: cross sectional study from European Community respiratory health survey. BMJ 2002 ; 325 : 411-4.

Cliccare qui per andare alla sezione Riferimenti]}^{[5Demenais F, Chaudru V, Martinez M : Detection of parent-of-origin effects for atopy by model-free and model-based linkage analyses. Genet Epidemiol 2001 ; 21 : S186-91.

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En biologie ^[]^{[7Benayoun L, Druilhe A, Dombret MC, Aubier M, Pretolani M : Airway structural alterations selectively associated with severe asthma. Am J Respir Crit Care Med 2003 ; 167 : 1360-8.

Cliccare qui per andare alla sezione Riferimenti]}^{[8Berger P, Girodet PO, Begueret H, Ousova O, Perng DW, Marthan R, Walls AF, Tunon de Lara JM : Tryptase-stimulated human airway smooth muscle cells induce cytokine synthesis and mast cell chemotaxis. FASEB Journal 2003 ; 17 : 2139-41.

Cliccare qui per andare alla sezione Riferimenti]}^{[9Da Silva CA, Heilbock C, Kassel O, Frossard N : Transcription of stem cell factor (SCF) is potentiated by glucocorticoids and interleukin-1beta through concerted regulation of a GRE-like and an NF-kappaB response element. FASEB Journal 2003 ; 17 : 2334-6.

Cliccare qui per andare alla sezione Riferimenti]}^{[10Senechal S, de Nadai P, Ralainirina N, Scherpereel A, Vorng H, Lassalle P, Tonnel AB, Tsicopoulos A, Wallaert B : Effect of diesel on chemokines and chemokine receptors involved in helper T cell type 1/type 2 recruitment in patients with asthma. Am J Respir Crit Care Med 2003 ; 168 : 215-21.

Cliccare qui per andare alla sezione Riferimenti]}^{[11Fahy O, Senechal S, Pene J, Scherpereel A, Lassalle P, Tonnel AB, Yssel H et coll : Diesel exposure favors Th2 cell recruitment by mononuclear cells and alveolar macrophages from allergic patients by differentially regulating macrophage-derived chemokine and IFN-gamma-induced protein-10 production. J Immunol 2002 ; 168 : 5912-9.

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En recherche clinique

Quel rôle pour les organismes dans la recherche sur l’asthme dans les dix prochaines années ?