Sentinel lymph node biopsy status improves adjuvant therapy decision-making in patients with clinical stage IIB/C melanoma: A population-based analysis - 16/03/23
, Richard J. Straker, MD a, Phyllis A. Gimotty, PhD b, Emily Y. Chu, MD, PhD c, Tara C. Mitchell, MD d, John T. Miura, MD a, Michael A. Marchetti, MD e, Edmund K. Bartlett, MD f, Giorgos C. Karakousis, MD aAbstract |
Background |
Given the results of the recent KEYNOTE-716 trial, the performance of sentinel lymph node (SLN) biopsy for patients with clinical stage IIB/C melanoma has been questioned.
Objective |
Determine the utility of SLN status in guiding the recommendations for adjuvant therapy.
Methods |
Patients with clinical stage IIB/C cutaneous melanoma who underwent wide local excision and SLN biopsy between 2004 and 2011 were identified from the Surveillance, Epidemiology, and End Results database. Two prognostic models, with and without SLN status, were developed predicting risk of melanoma-specific death (MSD). The primary outcome was net benefit at treatment thresholds of 20% to 40% risk of 5-year MSD.
Results |
For the 4391 patients included, the 5-year MSD rate was 46%. The model estimating 5-year MSD risk that included SLN status provided greater net benefit at treatment thresholds from 30% to 78% compared to the model without SLN status. The added net benefit for the SLN biopsy-containing model persisted in subgroup analysis of patients in different age groups and with various T stages.
Limitations |
Retrospective study.
Conclusions |
A prognostic model with SLN status estimating patient risk for 5-year MSD provides superior net benefit compared to a model with primary tumor staging factors alone for threshold mortality rates ≥30%.
Il testo completo di questo articolo è disponibile in PDF.Key words : decision analysis, immune therapy, melanoma, prognosis, sentinel lymph node biopsy, surgery, survival, wide local excision
Abbreviations used : AAPI, AJCC, AUC, CP, IQR, MSD, NOS, PD1, ROC, SEER, SLN, SLNB
Mappa
| Drs Sharon and Straker contributed equally to this study as lead authors. |
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| Funding sources: Dr Karakousis's efforts were supported by the National Cancer Institute SPORE in Skin Cancer, SP50 CA 261608. |
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| IRB approval status: Reviewed by the University of Pennsylvania Institution Review Board, approval given for use of SEER data (protocol # 53183). |
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| Patient consent: No identifiable material, including photographs or identifiable medical information, is included in this manuscript. All included data is de-identified, and as such, no IRB approval was required for this specific study, although it was required for use of the SEER data (see below). |
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| Reprints not available from the authors. |
Vol 88 - N° 4
P. 802-807 - aprile 2023 Ritorno al numero
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