Host and primary tumor factors for the development of multiple cutaneous squamous cell carcinomas among a retrospective cohort in Rhode Island - 18/08/23
Abstract |
Introduction |
Risk factors for a primary cutaneous squamous cell carcinoma (CSCC) are well-established; however, the host and primary tumor risk factors for subsequent CSCC have not been fully explored.
Methods |
We performed a retrospective chart review of patients diagnosed with CSCC in an academic dermatology clinic in Rhode Island from 2016-2019. Logistic regression was used to evaluate the associations between host factors and multiple CSCC and between primary tumor characteristics and the risk of subsequent CSCC. Adjusted odds ratios (aORs) and 95% CIs were calculated.
Results |
A total of 1312 patients with CSCC diagnoses were included. Host risk factors significantly associated with multiple CSCCs included: aged >80 years (aOR, 2.18; 95% CI, 1.46-3.31); history of: solid organ transplant (aOR, 2.41; 95% CI, 1.20-4.80); skin cancer (aOR, 1.96; 95% CI, 1.52-2.54); other cancer (aOR, 1.49; 95% CI, 1.11-2.00); family history of skin cancer (aOR, 1.36; 95% CI, 1.03-1.78); and actinic keratosis (aOR, 1.52; 95% CI, 1.18-1.95). Tumor location, diameter, histologic differentiation, and treatment were not significant predictors of subsequent CSCCs.
Limitations |
Study patients were predominantly White and from a single institution, limiting the generalizability of results.
Conclusions |
Certain host characteristics were associated with the development of subsequent CSCC, which may inform clinical guidelines for follow-up.
Il testo completo di questo articolo è disponibile in PDF.Key words : epidemiology, general dermatology, medical dermatology, nonmelanoma skin cancer, oncology, squamous cell carcinoma
Abbreviations used : aOR, BCC, CSCC, NMSC
Mappa
| Funding sources: None. |
|
| IRB approval status: This study was reviewed and approved by the Lifespan IRB (#1526450). |
Vol 89 - N° 3
P. 511-518 - settembre 2023 Ritorno al numero
Articolo precedente
- Androgenetic alopecia incidence in transgender and gender diverse populations: A retrospective comparative cohort study
- Julia L. Gao, Jessika Sanz, Nicholas Tan, Dana S. King, Anna M. Modest, Erica D. Dommasch
- Prevalence and burden of atopic dermatitis involving the head, neck, face, and hand: A cross sectional study from the TARGET-DERM AD cohort
- Jonathan I. Silverberg, Brenda Simpson, Katrina Abuabara, Emma Guttman-Yassky, Brian Calimlim, Colleen Wegzyn, Whitney Krueger, Amy Gamelli, Breda Munoz, Rachel W. Faller, Julie M. Crawford, Ayman Grada, Lawrence F. Eichenfield, TARGET-DERM Investigators
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?