Characteristics of pathologic complete response for locally advanced rectal cancer - 22/11/23
Abstract |
Background |
Neoadjuvant chemoradiation (NACRT) is the standard of care for locally advanced rectal cancers. The purpose of this study was to determine patient and tumor factors associated with a pathologic complete response (pCR).
Methods |
The National Surgical Quality Improvement Program proctectomy-targeted database was utilized to identify all patients from 2016 to 2020 who underwent NACRT followed by proctectomy with curative intent for T3-4N0-2 rectal cancers.
Results |
A total of 1891 patients were included, of which 253 (13.4%) demonstrated a pCR. Pretreatment N0 staging was associated with a higher rate of pCR (18.9%) when compared to N1 (6.7%) and N2 (6.7%) (p < 0.0001). Patients clinically staged at T3N0 had the highest rate of pCR (19.5%). Gender, age, race, weight, smoking status, and tumor height were not associated with pCR.
Conclusions |
Patients with cN0 disease were more likely to experience a pCR compared to cN1-2 patients. Tumor height relative to anal verge or patient demographics were not associated with pCR.
Il testo completo di questo articolo è disponibile in PDF.Highlights |
• | Pretreatment nodal staging is associated with pathologic complete response. |
• | Tumor height is not associated with rates of pathologic complete response. |
• | Understanding associative factors guide patient treatment counseling. |
Keywords : Rectal cancer, Pathologic complete response, Associative factors
Mappa
Vol 226 - N° 6
P. 873-877 - dicembre 2023 Ritorno al numero
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