Generalized Pustular Psoriasis, Acute Generalized Exanthematous Pustulosis, and Other Pustular Reactions : A Clinical Review - 27/02/24

Doi : 10.1016/j.det.2024.01.001

Elisabeth Gössinger, MD ^a, Roni Dodiuk-Gad, MD ^b,^c, Beda Mühleisen, MD ^a, Hazel H. Oon, MD ^b,^d, Choon Chiat Oh, MD ^e,^f, Julia-Tatjana Maul, MD ^g, Alexander A. Navarini, MD, PhD ^a,^h,^i,^j,^⁎
^a Department of Dermatology, University Hospital of Basel, Burgfelderstrasse 101, Basel 4055, Switzerland
^b Department of Dermatology, Emek Medical Center, Bruce Rappaport Faculty of Medicine, Technion Institute of Technology, Haifa, 3525433 Israel
^c Division of Dermatology, Department of Medicine, University of Toronto, Toronto, Ontario M5S 1A1, Canada
^d National Skin Centre and Skin Research Institute of Singapore (SRIS), 1 Mandalay Road, Singapore 308205, Singapore
^e Department of Dermatology, Singapore General Hospital, Singapore, Singapore
^f Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore
^g Department of Dermatology, University Hospital of Zurich and Faculty of Medicine, Zurich 8091/8006, Switzerland
^h Department of Biomedical Research, University of Basel, Allschwil 4123, Switzerland
ⁱ Department of Biomedical Engineering, University of Basel, Allschwil 4123, Switzerland
^j Department of Clinical Research, University of Basel, Allschwil 4123, Switzerland

^∗Corresponding author.

Riassunto

Generalized pustular rashes have various etiologies and can be challenging to diagnose and manage at first presentation. The authors provide an in-depth analysis of common pustular skin eruptions including generalized pustular psoriasis (GPP) and acute generalized exanthematous pustulosis, focusing on their pathophysiology, triggers, clinical presentation, diagnostic challenges, and management strategies. The article also highlights recent advances in genetic research and biologic therapies for GPP and the future directions in personalized medicine and prevention strategies.

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Keywords : Generalized pustular psoriasis, Acute generalized exanthematous pustulosis, Pustular skin eruptions, IL-36 pathway, Genetic mutations, Drug-induced reactions, Biologic therapies

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Key points

Introduction

Pathophysiology, triggers

Clinical features and differentiation

Generalized Pustular Psoriasis

Acute Generalized Exanthematous Pustulosis

Other Pustular Conditions

Dermatopathology

Treatment

International Rare and Severe Psoriasis Expert Network prospective registry and future questions to be addressed

Clinics care points

Esportazione

Vol 42 - N° 2

P. 317-328 - aprile 2024 Ritorno al numero

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Generalized Pustular Psoriasis, Acute Generalized Exanthematous Pustulosis, and Other Pustular Reactions : A Clinical Review - 27/02/24

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