Hospital-based screening outperforms primary care screening as a means of achieving hepatitis C virus micro-elimination - 29/02/24
Graphical abstract |
Highlights |
• | Controversy exists on screening strategies designed to ensure HCV micro-elimination. |
• | Performances of a hospital-based and a primary care-centered HCV screening were assessed. |
• | Hospital screening significantly increased HCV case findings in comparison with primary care screening. |
• | Hospital-based HCV screening enhances the effectiveness of HCV micro-elimination programs. |
Abstract |
Aim |
To assess the respective performances of a HCV screening program in a hospital setting and a HCV screening model applied concomitantly in a primary care centre.
Methods |
Adult patients consecutively admitted to hospital for ambulatory surgery were screened for anti-HCV antibodies (hospital screening cohort, HPSC), as were patients receiving blood tests for medical reasons in a primary care centre (primary care screening cohort, PCSC). Serum anti-HCV and HCV RNA levels were tested by ELISA and real-time PCR, respectively.
Results |
Seroprevalence of HCV infection was 2.2 % in the HPSC and 1.4 % in the PCSC (p = 0.044). All viraemic patients (0.2 % in HPSC and 0.1 % in PCSC) were treated with direct-acting antivirals and 85.7 % experienced a sustained virological response.
Conclusions |
Hospital-based HCV screening outperformed primary care-centered screening, significantly increasing HCV case findings.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Screening, Hepatitis C virus, Micro-elimination, Antiviral therapy
Abbreviations : HCV, HPSC, PCSC, WHO, DAA
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Vol 54 - N° 2
Articolo 104855- marzo 2024 Ritorno al numero
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