Pilose antler extract promotes hair growth in androgenic alopecia mice by promoting the initial anagen phase - 27/04/24
Abstract |
Androgenetic alopecia (AGA) is a prevalent disease in worldwide, local application or oral are often used to treat AGA, however, effective treatments for AGA are currently limited. In this work, we observed the promoting the initial anagen phase effect of pilose antler extract (PAE) on hair regeneration in AGA mice. We found that PAE accelerated hair growth and increased the degree of skin blackness by non-invasive in vivo methods including camera, optical coherence tomography and dermoscopy. Meanwhile, HE staining of sagittal and coronal skin sections revealed that PAE augmented the quantity and length of hair follicles, while also enhancing skin thickness and hair papilla diameter. Furthermore, PAE facilitated the shift of the growth cycle from the telogen to the anagen phase and expedited the proliferation of hair follicle stem cells and matrix cells in mice with AGA. This acceleration enabled the hair follicles to enter the growth phase at an earlier stage. PAE upregulated the expression of the sonic hedgehog (SHH), smoothened receptor, glioma-associated hemolog1 (GLI1), and downregulated the expression of bone morphogenetic protein 4 (BMP4), recombinant mothers against decapentaplegic homolog (Smad) 1 and 5 phosphorylation. This evidence suggests that PAE fosters hair growth and facilitates the transition of the growth cycle from the telogen to the anagen phase in AGA mice. This effect is achieved by enhancing the proliferation of follicle stem cells and matrix cells through the activation of the SHH/GLI pathway and suppression of the BMP/Smad pathway.
Il testo completo di questo articolo è disponibile in PDF.Graphical Abstract |
Highlights |
• | Pilose antler extract promotes the proliferation of hair matrix cells and hair follicle stem cells to treat androgenic alopecia. |
• | Pilose antler extract affects SHH, SMO and GLI1 in hair follicle stem cells. |
• | Pilose antler extract affects BMP4, BMPR1A and phosphorylation of SMAD1/5 in hair matrix cells. |
• | When evaluating the changes in the SHH/GLI1 pathway, all mice need to be during and before the anagen III. |
Keywords : Androgenic alopecia, Pilose antler extract, Hair follicle growth cycle, SHH/GLI, BMP/Smad
Mappa
Vol 174
Articolo 116503- Maggio 2024 Ritorno al numeroBenvenuto su EM|consulte, il riferimento dei professionisti della salute.
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