Co-administration of “L-Lysine, Vitamin C, and Zinc” increased the antioxidant activity, decreased insulin resistance, and improved lipid profile in streptozotocin-induced diabetic rats - 27/04/24
Abstract |
Purpose |
We previously showed the beneficial effect of L-Lysine (Lys), a chemical chaperone, on reducing diabetic complications in diabetic rats and type 2 diabetic patients. Herein, we evaluated the effect of Lys co-administration with Vitamin C and Zinc (Lys+VC+Zn), in diabetic rats.
Methods |
The streptozotocin (50 mg/Kg) was injected into male adult Wistar rats to induce diabetes. Then, different groups of normal and diabetic rats were treated with Lys and Lys+VC+Zn for five months. So, there were 0.1 % Lys in the drinking water of both groups. The control groups received water alone. During the experiment, the body weight, and various parameters were determined in the blood, serum/plasma, and urine of the rats.
Results |
The determination of biochemical indexes confirmed diabetes induction and its complications in rats. Treatment with either Lys or Lys+VC+Zn resulted in reduced blood glucose and protein glycation (decreasing AGEs and HbA1c), increased insulin secretion, alleviated insulin resistance and HOMA-IR, improved lipid profile and HDL functionality (LCAT and PON1), enhanced antioxidant status (FRAP and AOPP), improved kidney function (decreased microalbuminuria, serum urea, and creatinine), and increased chaperone capacity (HSP70). Lys+VC+Zn showed better effects on these parameters than Lys alone.
Conclusions |
The results of this study indicated that co-administration of Lys, a chemical chaperone, with two antioxidants (VC and Zn) potentiates its antidiabetic effects and prevent diabetic complications in rat model of diabetes.
Il testo completo di questo articolo è disponibile in PDF.Graphical Abstract |
Highlights |
• | Lys+VC+Zn improved diabetic markers in rats more effective than Lys alone. |
• | Lys+VC+Zn reduced blood glucose and improved insulin resistance in diabetic rats. |
• | Lys+VC+Zn inhibited non-enzymatic protein glycation, AGEs and HbA1c formation. |
• | Lys+VC+Zn effectively mitigated diabetic nephropathy markers. |
• | Lys+VC+Zn improved lipid profile and anti-oxidative status in diabetic rats. |
Keywords : Diabetic Complications, Protein glycation, Insulin resistance, Kidney function, Antioxidant, HSP70
Mappa
Vol 174
Articolo 116525- Maggio 2024 Ritorno al numero
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