Potential therapeutic applications of circular RNA in acute kidney injury - 27/04/24
Abstract |
Acute kidney injury (AKI) is a common clinical syndrome characterized by a rapid deterioration in renal function, manifested by a significant increase in creatinine and a sharp decrease in urine output. The incidence of morbidity and mortality associated with AKI is on the rise, with most patients progressing to chronic kidney disease or end-stage renal disease. Treatment options for patients with AKI remain limited. Circular RNA (circRNA) is a wide and diverse class of non-coding RNAs that are present in a variety of organisms and are involved in gene expression regulation. Studies have shown that circRNA acts as a competing RNA, is involved in disease occurrence and development, and has potential as a disease diagnostic and prognostic marker. CircRNA is involved in the regulation of important biological processes, including apoptosis, oxidative stress, and inflammation. This study reviews the current status and progress of circRNA research in the context of AKI.
Il testo completo di questo articolo è disponibile in PDF.Graphical Abstract |
Highlights |
• | Incidence of AKI is increasing owing to RIRI, sepsis, and nephrotoxic drugs. |
• | CircRNAs highly stable and most abundantly expressed in kidney. |
• | Regulating circRNA expression attenuates AKI. |
• | Attenuation achieved via effects on apoptosis, inflammation, and oxidative stress. |
• | CircRNA-targeting interventions may help repair AKI damage. |
Keywords : Circular RNA, Acute kidney injury, Renal ischemia-reperfusion injury, Sepsis, Application
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Vol 174
Articolo 116502- Maggio 2024 Ritorno al numeroBenvenuto su EM|consulte, il riferimento dei professionisti della salute.
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