Retrospective, propensity score--matched study examining the relationship between frailty and Clostridioides difficile infection in a national cohort of US veterans - 13/11/24
, Kelsey A. Strey, PharmD a, b, Esther L. Albuquerque a, b, Damaris Jacota a, b, Xavier Jones, BS a, c, Joseph J. Carreno, PharmD, MPH dRiassunto |
Background |
Frailty is often more predictive of disease and mortality compared with chronological age. This study determined the impact of frailty on Clostridioides difficile infection (CDI) risk and outcomes in a national veteran population.
Methods |
This was a retrospective cohort study of CDI and control veteran inpatients and outpatients from fiscal year 2003 to 2018. Baseline frailty was presented as the Veterans Affairs (VA) Frailty Index. Propensity score--matched analyses were conducted to compare CDI risk, CDI health outcomes, and 1-year new-onset frailty-associated conditions.
Results |
A total of 11,451 CDI and 11,451 matched control patients were included. Baseline frailty conditions were more common among CDI patients, especially involuntary weight loss (6.0% vs 3.4%, P < .001) and anemia (24.6% vs 18.7%, P < .001). VA Frailty Index was significantly higher for CDI patients (0.13 vs 0.11, P = .019). Frail CDI patients were more likely to experience 30-day mortality (11.3% vs 1.1%, P < .001) and 60-day CDI recurrence (20.4% vs 16.3%, P < .001) compared with non-/prefrail CDI patients. At 1year, CDI patients were significantly more likely to be categorized as frail (19.6% vs 17.0%, P < .001).
Conclusions |
This study demonstrated the potential association between frailty and CDI risk and health outcomes, as well as new-onset frailty diagnoses in patients who develop CDI.
Il testo completo di questo articolo è disponibile in PDF.Highlights |
• | Clostridioides difficile infection (CDI) and frailty was studied in US veterans. |
• | Frailty conditions were more common among CDI patients compared with non-CDI patients. |
• | Frail CDI patients were more likely to experience mortality and CDI recurrence. |
• | At 1year, CDI patients were more likely to be frail compared with non-CDI patients. |
Key Words : Mortality, Epidemiology
Mappa
| Conflicts of interest: None to report. |
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| Funding/support: Institutional funding from The University of Texas at Austin was used to support this work. Additionally, KRR is supported by the National Institutes of Health (UM1TR004538, P30AG044271). |
Vol 52 - N° 12
P. 1412-1418 - dicembre 2024 Ritorno al numero
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