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Adipose derived stem cells – Sources, differentiation capacity and a new target for reconstructive and regenerative medicine - 22/04/25

Doi : 10.1016/j.biopha.2025.118036 
Małgorzata Suchanecka a, Joanna Grzelak a, Maryam Farzaneh b, Shirin Azizidoost c, Mahrokh Abouali Gale Dari d, Małgorzata Józkowiak a, e, Krzysztof Data a, Dominika Domagała a, Julia Niebora a, Katarzyna Kotrych f, Bogusław Czerny g, h, Adam Kamiński i, Natalia Torlińska-Walkowiak j, Andrzej Bieniek k, Jacek Szepietowski l, m, Hanna Piotrowska-Kempisty e, n, Piotr Dzięgiel o, Paul Mozdziak p, Bartosz Kempisty a, q, r, s, ⁎
a Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, Wroclaw 50-368, Poland 
b Fertility, Infertility and Perinatology Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 
c Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 
d Department of Obstetrics and Gynecology, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran 
e Department of Toxicology, Poznan University of Medical Sciences, Poznań 61-631, Poland 
f Department of General and Dental Radiology, Pomeranian Medical University in Szczecin, Powstańców Wielkopolskich 72, Szczecin 70-111, Poland 
g Department of General Pharmacology and Pharmacoeconomics, Pomeranian Medical University in Szczecin, Żołnierska 48, Szczecin 71-230, Poland 
h Department of Stem Cells and Regenerative Medicine, Institute of Natural Fibres and Medicinal Plants, Kolejowa 2, Plewiska 62-064, Poland 
i Department of Pediatric Orthopedics and Musculosceletal Oncology, Pomeranian Medical University 
j Department of Paediatric Dentistry, Poznan University of Medical Sciences, Poznań, Poland 
k University Center for General and Oncological Dermatology, Wroclaw Medical University, Wroclaw 50-367, Poland 
l Faculty of Medicine, Wroclaw University of Science and Technology, Wroclaw, Poland 
m Department of Dermato-Venereology, 4th Military Hospital, Wroclaw, Poland 
n Department of Basic and Preclinical Sciences, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, Torun 87-100, Poland 
o Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, Wroclaw 50-368, Poland 
p Graduate Physiology Program, North Carolina State University, Raleigh, NC 27695, USA 
q Center of Assisted Reproduction, Department of Obstetrics and Gynecology, University Hospital and Masaryk University, Brno 625 00, Czech Republic 
r Department of Veterinary Surgery, Institute of Veterinary Medicine, Nicolaus Copernicus University in Torun, Torun 87-100, Poland 
s North Carolina State University College of Agriculture and Life Sciences, Raleigh, NC 27695, USA 

⁎ Corresponding author at: Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University, Wroclaw 50-368, Poland. Division of Anatomy, Department of Human Morphology and Embryology, Faculty of Medicine, Wroclaw Medical University Wroclaw 50-368 Poland

Abstract

Adipose-derived stem cells (ADSCs) are mesenchymal stem cells (MSCs) derived from adipose tissue with mesenchymal lineage differentiation potential and remarkable potential in regenerative medicine. ADSCs are easily sourced from adipose tissue, share regenerative characteristics akin to other MSCs. Their convenient adherence to plastic culture flasks, coupled with their capacity for in vitro expansion and multi-lineage differentiation, underscores their promise as a robust tool for tissue repair and enhancement. The accessibility of human adipose tissue and the development of minimally invasive isolation protocols have further propelled the autologous use of ADSCs, fueling excitement in both organ repair and regenerative medicine. Consequently, research in ADSCsis experiencing rapid growth. A detailed overview of the current landscape of ADSCs isolation and differentiation capacity including the latest advancements in ADSCs usage, encompassing ongoing clinical investigations are important considerations to understand their potential to shape the landscape of regenerative medicine.

Il testo completo di questo articolo è disponibile in PDF.

Graphical Abstract




Il testo completo di questo articolo è disponibile in PDF.

Keywords : Adipose-derived stem cells, Mesenchymal stem cells, Adipocytes, Regenerative medicine


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© 2025  The Authors. Pubblicato da Elsevier Masson SAS. Tutti i diritti riservati.
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