Relationship between sweat chloride and pulmonary function in healthy young adults – a single-center, pilot study - 02/07/25
, Alison T. Lennox a, b, John Welter a, b, c, Allen J. Dozor a, b, cAbstract |
Background |
The role of Cystic Fibrosis Transmembrane Conductance regulator (CFTR) dysfunction in non-cystic fibrosis lung diseases, including COPD, is not well understood. The objective of this study was to assess the prevalence of intermediate sweat chloride levels, 30–59 mmol/L, in healthy young adults and the relationship between sweat chloride and pulmonary function.
Methods |
Healthy volunteers >18 years of age were enrolled in this single center, prospective, cross-sectional pilot study. Sweat chloride testing was performed by pilocarpine iontophoresis. Study participants completed the ATS-DLD LHS-III modified general respiratory symptom questionnaire, spirometry pre- and post-inhaled bronchodilator, and Lung Clearance Index.
Results |
93 subjects were enrolled. 1 subject withdrew and 2 had insufficient sweat volumes collected. Median (IQR) age was 27 years (25, 33) and 40 % were male. Median (IQR) sweat chloride was 21 mmol/L (12, 29). 25/90 subjects (28 %) had intermediate sweat chloride values, median 37 (33, 40) mmol/L. 60 % of individuals with intermediate sweat chloride values were male as compared to 34 % of individuals with normal sweat chloride values, p < 0.001. Median FEV 1 (% predicted) was 100 (90, 109), FEV 1 /FVC 0.83 (0.81, 0.86), and LCI was 6.01 (5.38, 6.98). There were no differences in pulmonary function between those with normal and intermediate sweat chloride values.
Conclusions |
A significant number of healthy young adults have intermediate sweat chloride levels, but no differences in spirometry and LCI were found. Larger studies, including genetic analyses, are needed to determine if mild CFTR dysfunction impacts respiratory health, especially in older individuals with respiratory co-morbidities.
Il testo completo di questo articolo è disponibile in PDF.Highlights |
• | Healthy young adults may have intermediate sweat chloride levels. |
• | Such intermediate sweat chloride levels may indicate suboptimal CFTR function. |
• | These intermediate levels do not affect lung function by spirometry or LCI. |
• | Mutation analysis of CFTR genes is needed to correlate with these results. |
• | Impact of prolonged CFTR dysfunction on long-term respiratory health is not known. |
Riassunto |
American Thoracic Society International conference, May 19–23, 2023, Washington DC. The abstract was published as part of the proceedings of the conference: Krishnan SS, Lennox A, Welter JJ, Dozor AJ. Relationship Between Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Function, and Pulmonary Function in Young Adults. Am J Respir Crit Care Med 2023; 207:A4068.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Cystic fibrosis, CFTR, Sweat chloride, Spirometry, Lung clearance index, COPD
Mappa
| ☆ | •All co-authors have reviewed and approved the content of the manuscript, including the data and analyses. |
| ☆☆ | •This work is clinically relevant, as there is increasing evidence that adults with intermediate sweat chloride levels are at increased risk for lung disease. |
| ☆☆☆ | •Though there are other publications related to the subject of this manuscript, there are none describing testing healthy young adults. |
Vol 245
Articolo 108177- agosto 2025 Ritorno al numero
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