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Association between 6-min walk test and initiation of home oxygen therapy within 3 years in chronic obstructive pulmonary disease managed by primary care physicians - 01/09/25

Doi : 10.1016/j.rmed.2025.108317 
Hiromi Muraoka a, b, Takahiro Tsuburai a, b, , Yuko Komase a, Satoshi Tanaka a, b, Asami Moriuchi a, b, Shotaro Kaneko a, b, Makoto Nishida a, b, Junko Shibuya Ueno a, b, Aya Matsushima a, b, Yusuke Shinozaki a, b, Kazuhiro Nishiyama a, b, Yoshihiro Nishi a, b, Yu Numata a, b, Hajime Tsuruoka a, b, Baku Oyama a, b, Naoya Hida a, Masamichi Mineshita b, Takeo Inoue a, b, Hiroki Nishine a
a Department of Respiratory Medicine, St. Marianna University Yokohama Seibu Hospital, Yasashicho 1197-1, Asahi, Yokohama, Kanagawa, Japan 
b Department of Respiratory Medicine, St. Marianna University School of Medicine, Sugao 2-16-1, Miyamae, Kawasaki, Kanagawa, Japan 

Corresponding author. Department of Respiratory Medicine, St. Marianna University School of Medicine Sugao 2-16-1, Miyamae, Kawasaki, Kanagawa, 216-8511, Japan Department of Respiratory Medicine St. Marianna University School of Medicine Sugao 2-16-1 Miyamae Kawasaki Kanagawa 216-8511 Japan

Abstract

Background

In the western area of Yokohama, patients with mild chronic obstructive respiratory disease (COPD) are managed via a coordinated system consisting of St. Marianna University Yokohama Seibu hospital and primary care clinics. In this study, we investigated whether background factors predicted the need for home oxygen therapy (HOT) within three years as a marker of risk for exacerbation and hospitalization.

Methods

Of the 114 COPD patients who were managed via the coordinated system between January 2013 and March 2020, 101 who underwent the 6-min walk test (6MWT) in room air were recruited.

Results

The mean age of patients was 76.2 years, and 95 were male. The mean distance covered during the 6MWT (6MWD) was 374 m, and the median lowest SpO 2 during the 6MWT was 93 %. Twenty-two patients dropped out of the study. Eleven patients (10.8 %) required HOT within 3 years. Compared with the 68 patients who did not require HOT, the group requiring HOT was significantly older, covered a had a short 6MWD, had a lower SpO 2 , a lower percentage diffusing capacity of the lung for carbon monoxide (%DLCO), and a higher right ventricular systolic pressure (RVSP). Receiver operating characteristic curve analysis revealed a cut off value of 91 % in the lowest SpO 2 for the introduction of HOT within 3 years (Area under the curve: 0.819, sensitivity: 1.0, specificity: 0.633).

Conclusion

The 6MWT can be used to assess cardiopulmonary function in COPD and associated with prognosis. 6MWT can be useful predictor of a future need for HOT.

Il testo completo di questo articolo è disponibile in PDF.

Highlights

A retrospective study was conducted to investigate risk factors for home oxygen introduction 3 years later in COPD patients managed through collaboration between primary care physicians and hospitals.
Patients who introduced HOT within 3 years were characterized by a shorter distance in the 6-min walk test and a lower minimum SpO2 %.
The 6-min walk test may be able to predict the risk of HOT introduction in primary care physician management.

Il testo completo di questo articolo è disponibile in PDF.

Keywords : Chronic obstructive pulmonary disease, Home oxygen therapy, Primary care, 6-Min walk test


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© 2025  The Authors. Pubblicato da Elsevier Masson SAS. Tutti i diritti riservati.
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