Bisphenols are ubiquitous endocrine disruptors, which are suspected of being responsible for the disruption of various physiological functions. However, their effect on the perinatal period remains poorly understood despite the importance of this stage of development.

The main objective of this work was to evaluate the profile of fetal exposure to three types of bisphenols. The second objective was to study the possible associations between hormone and bisphenols levels and to examine the link between these disruptors and potential sources of exposure.

One hundred and fifty-four mother-newborn pairs were selected and cord blood samples were collected. The evaluation of six hormones (FSH, LH, Testosterone, Estradiol, Progesterone, and Prolactin) was conducted on these samples, as well as the determination of three types of bisphenols (BPA, BPS, and BPF).

The percentages of bisphenols found in umbilical blood samples were 92.8%, 65.5%, and 57.8% for BPA, BPS, and BPF. The average concentrations were 2.456ng/mL for BPA, 0.646ng/mL for BPS, and 0.660ng/mL for BPF. Positive associations were found between the concentration of estradiol and the levels of the three types of bisphenols. Besides, a positive association was found between the concentrations of prolactin and BPA. As far as the sources of exposure are concerned, no significant association could be established.

The obtained results suggest potential endocrine-related effects of bisphenols. Additional studies, including experimental and longitudinal designs, are needed to confirm these associations and clarify causal relationships.