Assessment of two olfactory training methods for post-COVID-19 loss of olfaction: Classical and intensive - 08/11/25
, P.L. Nguyen-Thi b, P. Gallet a, R. Jankowski a, C. Rumeau a, D.T. Nguyen a, ⁎
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Abstract |
Objectives |
To determine whether intensive olfactory training provides better chances of recovery than classic protocols in persistent dysosmia after Covid-19.
Introduction |
In the literature, olfactory training holds pride of place in the management of post-infection olfactory disorder, with a classic 4-odor protocol. On the other hand, few studies have assessed the benefit of more intensive training.
Materials and methods |
This prospective randomized clinical trial (No. 2020-A01397-32) assessed olfactory training for persistent dysosmia due to COVID-19, with 5 weeks’ to 12 months’ progression. Patients were divided between 2 groups, receiving a classical 4-odor protocol (n=49) or an intensive 8-odor protocol (n=30). Olfaction was assessed in consultation on the Sniffin’ Sticks test, the DyNaChron self-reported olfaction questionnaire and a visual analogue scale (VAS), at inclusion (V1) and at 4 and 8 months (V2 and V3, respectively).
Results |
Both protocols significantly improved subjective olfactory assessment on VAS, with non-significant trends for improvement on psychophysical tests. There was no significant difference in olfactory recovery between the classic and intensive protocols. Adhesion to the training program decreased markedly beyond 4 months.
Conclusion |
Intensive olfactory training did not increase the chances of olfactory recovery compared to the classic protocol in a population with persistent dysosmia following COVID-19 infection.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Post-viral anosmia and hyposmia, COVID-19, Olfactory training, Sniffin’ Sticks test, DyNaChron, VAS, SARS-CoV-2
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Vol 142 - N° 6
P. 294-300 - novembre 2025 Ritorno al numero
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