Active hand inflammation. Differing clinical and ultrasound patterns in patients with rheumatoid arthritis and psoriatic arthritis – A cross-sectional, multicenter study - 28/11/25
, Vicenç Torrente-Segarra b, Andrea Cuervo c, Mireia Moreno d, Ana Belén Azuaga a, Lourdes Mateo e, Beatriz Frade-Sosa a, Andrea Zacarías a, Noemí Busquets-Pérez c, Susana Holgado e, Paula Estrada f, Oscar Camacho f, Juan José De Agustín g, Carme Moragues h, María Bonet b, Sandra Farietta a, Patricia Corzo a, Andrés Ponce a, Virginia Ruiz-Esquide a, Lucía Alascio a, Juan D. Cañete aECOCAT Group
Highlights |
• | Certain ultrasound patterns, such as increased synovial pannus and paratenonitis, were characteristic of RA and PsA, respectively, although none of these patterns were exclusive to a specific condition. |
• | We found a strong association between ultrasound-detected synovial pannus and erosive disease, as well as paratenonitis and joint ankylosis. |
• | Overall, our study suggests that ultrasound correlates better with structural outcomes than with specific diagnoses. |
Abstract |
Objectives |
To define ultrasound (US) characteristics in patients with Rheumatoid Arthritis (RA) and Psoriatic Arthritis (PsA) exhibiting active hand inflammation.
Methods |
This cross-sectional, multicenter study collected epidemiological and clinical data from RA and PsA patients with active hand inflammation. US examinations of wrists and metacarpophalangeal joints were performed, focusing on extensor and flexor tendons.
Results |
A total of 292 patients were included: 192 (61.7%) were women, with a mean age of 56.1 years and mean disease duration of 105.4 months. Ninety-one patients (31.1%) had seropositive RA, 79 (27%) had seronegative RA, and 122 (41.7%) had PsA. Overall, 125 patients (42.8%) exhibited erosive disease, with 103 (35.2%) receiving targeted therapies. All patients had active disease (mean SDAI: 29.5; mean DAPSA: 22.3). Among the cohort, 144 patients (49.3%) showed synovial hypertrophy (SH) ≥ 2 + Power Doppler (PD). This was more common in seropositive (72.5%) than in seronegative RA (43%) or PsA (36%) ( P ≤ 0.001). Erosive disease (OR 8.4 [3.9–18], P ≤ 0.001) and US global score (OR 1.1 [1–1.1], P ≤ 0.001) were associated with SH ≥ 2 + PD. Extensor paratenonitis was more frequent in PsA (27%) compared to seropositive (9.8%) and seronegative RA (18.9%) ( P ≤ 0.01). The number of swollen joints (OR 1.1 [1–1.2], P ≤ 0.001) and joint ankylosis (OR 4.3 [1.1–16.9], P ≤ 0.05) were positively associated with paratenonitis.
Conclusions |
Synovial pannus was characteristic of RA, while paratenonitis was more common in PsA. SH ≥ 2 + PD correlated with erosive disease, highlighting the need for prospective studies to validate US as a decision-making tool in arthritis.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Rheumatoid arthritis, Psoriatic arthritis, Ultrasound, Imaging, Erosive disease
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Vol 92 - N° 6
Articolo 105916- dicembre 2025 Ritorno al numero
Articolo precedente
- Ultrasound in rheumatic and musculoskeletal diseases: From musculoskeletal to organ involvement
- Lyubomyra Kun, Irina Gessl, Georgios Filippou, Matteo Ferrito, Roberto Giacomelli, Peter Mandl
- Correlation of Naples prognostic score with the risk of all-cause and cardiovascular mortality in individuals with rheumatoid arthritis: A cross-sectional analysis of the NHANES 2001–2018
- Feiyue Zhou, Yuhan Xie, Yiran Zhang, Ping Jiang
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