Microfocused ultrasound with visualization (MFU-V) represents a noninvasive energy-based modality for skin tightening and lifting. This technology delivers precise ultrasound energy to dermal and subdermal tissues, creating thermal coagulation points that stimulate neocollagenesis and elastin regeneration. US Food Drug Administration-cleared for brow lifting, neck and submental tightening, and décolletage wrinkles, with recent 2025 clearance for abdomen and arms, MFU-V demonstrates efficacy across multiple anatomic regions with a favorable safety profile. The recent introduction of Ultherapy Prime offers enhanced visualization and processing capabilities, potentially improving treatment precision and patient comfort.