A Cloud Enabled Hybrid CNN Transformer Framework with Attention Mechanisms for Scalable Alzheimer’s Disease Staging from Structural MRI - 09/06/26

Doi : 10.1016/j.neuri.2026.100283 
R. Leelavathi 1 , D. Prabha Devi 2 , A. Kodieswari 3 , Arfat Ahmad Khan 4 , V. Suma 1 , Shahid Kamal 5, , Fasee Ullah 6
1 Department of Computer Science and Design, Dayananda Sagar College of Engineering, Bengaluru 
2 Department of Computer Science and Engineering, Bannari Amman Institute of Technology, Sathyamangalam 
3 Department of Artificial Intelligence and Machine Learning, Bannari Amman Institute of Technology, Sathyamangalam 
4 Department of Computer Science, College of Computing, Khon Kaen University, Khon Kaen 40002, Thailand 
5 Faculty of Computing and Informatics, Multimedia University, Cyberjaya, Selangor, Malaysia 
6 Department of Computing, Universiti Teknologi PETRONAS, vSeri Iskandar, Perak, Malaysia 

Corresponding Author:

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In corso di stampa. Manoscritto Accettato. Disponibile online dal Tuesday 09 June 2026
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Abstract

Alzheimer's disease (AD) is a neurodegenerative condition that causes cognitive impairment and structural brain changes, and early diagnosis is crucial for treatment. This paper proposes a cloud-based hybrid deep learning architecture for scalable Alzheimer's disease staging based on structural magnetic resonance imaging (MRI). The hybrid architecture leverages convolutional neural networks (CNNs), attention, and Transformer-based modeling to capture both local and global spatial features in MRI images. CNN extracts multi-dimensional features, while the attention and Transformer layers enrich context representation for more accurate staging of the disease. The framework was trained on a GPU-enabled computer using the PyTorch deep learning framework on a publicly available MRI dataset for Alzheimer's disease from the Kaggle website. The model was cross-validated on the OASIS dataset to assess its generalizability. The experimental findings showed that the proposed approach achieved an accuracy of 99.65% on the Kaggle dataset, which is better than several state-of-the-art deep learning models such as VGG16, ResNet variants, DenseNet121, EfficientNet-B0, and Vision Transformer. This approach also achieved an accuracy of 91.67% on the OASIS dataset, demonstrating the model's ability to generalize across neuroimaging datasets. To enable practical usage and accessibility, the trained model was also deployed in a cloud-based inference environment on Hugging Face Spaces, which allows MRI image upload and prediction from a web browser. The scalable and cloud-deployable design allows scalable medical image processing and integration with cloud-based diagnostic systems as well as telemedicine-based healthcare solutions. These findings demonstrate the potential for robust and accessible staging of Alzheimer's disease using the proposed framework in clinical settings.

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Keywords : Alzheimer’s disease, Structural MRI, Grad-CAM explainability, Hybrid CNN–Transformer, Attention mechanism, Deep learning, Multi-class classification


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