This article explores the regenerative peripheral nerve interface (RPNI) as an innovative solution for intuitive prosthetic control. Traditional control methods (myoelectric, brain–computer interfaces, and peripheral nerve interfaces) each have their own unique limitations. RPNI surgery involves implanting severed peripheral nerves into free skeletal muscle grafts to amplify action potentials and provide long-term signal stability. Preclinical studies in rats and nonhuman primates demonstrated the effectiveness of the RPNI in neural signal transduction, neuroma prevention, and long-term stability. Early human trials confirm its viability for volitional prosthetic control.