Relationship between baseline patient-reported health status and patient-centered outcomes after transcatheter aortic valve replacement - 08/07/26
on behalf of the
SCOPE I Investigators
Highlights |
• | Impaired Kansas City Cardiomyopathy Questionnaire-overall summary score (KCCQ-OS) was common in patients undergoing transcatheter aortic valve replacement (TAVR). |
• | Lower baseline KCCQ-OS was linked to greater post-TAVR gains. |
• | Despite larger gains, lower-baseline patients had worse follow-up status. |
• | Higher baseline KCCQ-OS was linked to 3-year survival in good health. |
ABSTRACT |
Background |
Aortic stenosis (AS) impairs health-related quality of life but the prognostic impact of patient-reported health status prior to transcatheter aortic valve replacement (TAVR) is not fully established.
Objectives |
To investigate the association of patient-reported health status at baseline with clinical outcomes and health status after transfemoral TAVR in patients with symptomatic severe AS.
Methods |
In the investigator-initiated, multicenter SCOPE I randomized trial, patients underwent TAVR who provided baseline Kansas City Cardiomyopathy Questionnaire (KCCQ) assessment were included in this post hoc analysis. An integrated patient-centered outcome was defined as being alive with good health status (KCCQ overall summary score [KCCQ-OS] ≥ 75 without a decline of > 10 points from baseline).
Results |
Of 739 patients enrolled in SCOPE I, 692 were included in the present analysis. Median baseline KCCQ-OS was 54.9 (39.6-71.9) distributed as follows: KCCQ-OS < 25-74 (10.7%), 25 to 49-222 (32.1%), 50 to 74-271 (39.2%), and ≥ 75-125 (18.1%). At 3 years after TAVR, higher baseline KCCQ-OS was associated with a greater likelihood of being alive with good health status (KCCQ-OS 50-75 vs 0-25: adjusted odds ratio 2.25, 95% confidence interval [CI] 1.12-4.54; 75-100 vs 0-25: adjusted odds ratio 5.15, 95% CI 2.33-11.3). Restricted cubic spline modelling demonstrated an approximately linear relationship between baseline KCCQ-OS and all-cause mortality, and alive with good health status.
Conclusions |
In this post hoc analysis of SCOPE I, better baseline patient-reported health status was associated with a higher probability of being alive with good health status up to 3 years after TAVR.
Clinical trial registration |
Mappa
Vol 300
Articolo 107495- ottobre 2026 Ritorno al numero
Articolo precedente
- Predictors of ischemic stroke and major bleeding among patients with atrial fibrillation in clinical practice
- Pishoy Gouda, Josephine Harrington, Kelly Arps, Gretchen Sanders, Anqi Chen, Karen Chiswell, Paul Hofmann, Keith Marsolo, Kirubel Asfaw, Rosa Coppolecchia, John H. Alexander, Jonathan Piccini, Christopher B. Granger, Heidi T. May, Elizabeth Chrischilles, Benjamin A. Steinberg, Alanna M. Chamberlain, Jeffrey VanWormer, William Schuyler Jones, Manesh R. Patel
- Potentially futile outcome after uncomplicated TAVI: Insights from the TRITAVI registry
- Fabrizio D’Ascenzo, Ovidio De Filippo, Francesco Pelliccia, Vincenzo Pasceri, George Dangas, Roxana Mehran, Italo Porto, Francesco Radico, Fausto Biancari, Francesco Saia, Giampaolo Luzi, Francesco Bedogni, Ignacio J. Amat Santos, Vincenzo De Marzo, Arnaldo Dimagli, Timo Mäkikallio, Samuele Sandrone, Eugenio Stabile, Sara B․-Turrión, Luca Testa, Marco Barbanti, Giuliano Costa, Franco Fabbiocchi, Ahmed Chilmeran, Giulio Stefanini, Federico Conrotto, Corrado Tamburino, Carmen Spaccarotella, Davide Cao, Andrea Macchione, Michele La Torre, Francesco Bendandi, Wojciech Wańha, Wojtek Wojakowski, Umberto Benedetto, Ciro Indolfi, David Hildick-Smith, Davide Capodanno, Fabio Miraldi, Dobromir Dobrev, Marco Zimarino, TRITAVI study group.
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?