Long-term outcome after endoscopic resection for esophageal squamous cell carcinoma invading muscularis mucosa without lymphovascular invasion: a multicenter retrospective study - 16/07/26
, Hiroshi Kawachi, MD, PhD 2, Satoshi Fujii, MD, PhD 3, Toshiyuki Yoshio, MD, PhD 4, Seiichiro Abe, MD, PhD 5, Yasuaki Nagami, MD, PhD 6, Ken-Ichi Mizuno, MD, PhD 7, Daisuke Kikuchi, MD, PhD 8, Yoichi Yamamoto, MD, PhD 9, Ryu Ishihara, MD, PhD 10, Tsuneo Oyama, MD, PhD 11, Hiroyoshi Nakanishi, MD, PhD 12, Chikatoshi Katada, MD, PhD 13, Yoshinobu Yamamoto, MD, PhD 14, Takuya Satomi, MD, PhD 15, Waku Hatta, MD, PhD 16, Yoshiyasu Kitagawa, MD, PhD 17, Kingo Hirasawa, MD, PhD 18, Yuji Urabe, MD, PhD 19, Jun Nakamura, MD, PhD 20, Noriaki Sugawara, MD, PhD 21, Tsutomu Tanaka, MD, PhD 22, Manabu Muto, MD, PhD 23, Masaki Tanaka, MD 24, Takashi Ikeno, PhD 25, Masashi Wakabayashi, MSc 26, Kaoru Nakano, MD 2, Atsushi Inaba, MD, PhD 1, Tomonori Yano, MD, PhD 1Abstract |
Background and Aims |
The need for additional treatment of patients with pathological (p)T1a–muscularis mucosa (MM) (pT1a–MM) esophageal squamous cell carcinoma (ESCC) without lymphovascular invasion (LVI) after endoscopic resection (ER) remains unclear because of the lack of large-scale studies with long-term follow-up. Thus, observations were generally selected as the community standard. We aimed to clarify the long-term outcomes for this patient group.
Methods |
Patients with pT1a–MM ESCC without LVI after ER were retrospectively recruited from 47 institutions between 2008 and 2015. The cumulative recurrence rate (CRR), overall survival (OS), and recurrence-free survival (RFS) were investigated.
Results |
Of the 540 patients included, 485 underwent observation, 45 received chemoradiotherapy (CRT), and 10 underwent surgery. The 5-year CRR, OS, and RFS rates for the observation, CRT, and surgery groups were 4.9%, 92.7%, and 89.6%; 2.2%, 93.3%, and 91.1%; and 10.0%, 100%, and 90.0%, respectively.
Conclusions |
Although CRR was not negligible, the current strategy of observation may be a reasonable option given the low recurrence risk.
Il testo completo di questo articolo è disponibile in PDF.Graphical abstract |
Abbreviations : CRR, CRT, ER, ESCC, ESD, IHC, LVI, MM, OS, p, RFS
Mappa
Vol 104 - N° 2
P. 286-292 - agosto 2026 Ritorno al numero
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