Data hiding techniques for biomedical signals: A comprehensive review of steganography and watermarking approaches - 04/09/26

Doi : 10.1016/j.neuri.2026.100292 
Bambang Ari Wahyudi a, b , Tohari Ahmad a, ⁎ , Royyana Muslim Ijtihadie a , Ntivuguruzwa Jean De La Croix c, d , Kambombo Mtonga e
a Department of Informatics, Institut Teknologi Sepuluh Nopember (ITS), Kampus ITS Keputih Sukolilo, Surabaya, 60111, Indonesia 
b School of Computing, Telkom University, Bandung, 40257, Indonesia 
c Faculty of Computing and Information Sciences, University of Lay Adventists of Kigali (UNILAK), Kigali, 6392, Rwanda 
d Department of Technology and Innovation, SecureAI Labs, Kigali, 6100, Rwanda 
e Mathematical Sciences Department, Malawi University of Business and Applied Sciences, Private Bag 303, Chichiri, Blantyre, 3, Malawi 

⁎ Corresponding author.

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Highlights

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A PRISMA-based systematic literature review screened 594 identified records, resulting in 54 papers for analysis.
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Presenting a structured taxonomy that classifies biomedical signal data hiding methods into classical and advanced categories, with advanced approaches based on optimization or machine learning.
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Trend analysis for biomedical signals and data hiding methods is conducted using linear trend analysis by estimating the slope and its corresponding confidence interval.
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Discusses the evaluation methods used to assess the imperceptibility, robustness, and capacity of biomedical signal data hiding techniques.

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Graphical abstract




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Abstract

Biomedical signals such as electrocardiography (ECG), electroencephalography (EEG), electromyography (EMG), and photoplethysmography (PPG) contain sensitive clinical information that requires robust protection during storage and transmission. Data hiding techniques, including steganography and watermarking, have been widely investigated to ensure confidentiality, integrity, and authentication while preserving the diagnostic quality of the original signal. This study presents a systematic literature review of biomedical signal data hiding research published between 2015 and 2025. Following the PRISMA methodology, 54 peer-reviewed journal articles were selected for detailed analysis. The reviewed studies were organized into a structured taxonomy comprising Classical and Advanced approaches. Classical methods, which include Time Domain, Transform Domain, and Hybrid Classical techniques, represent the dominant methodological group throughout the observed period. Advanced methods, encompassing Optimization-based, Intelligent, and Hybrid Advanced strategies, demonstrate a higher growth rate, reflecting an emerging shift toward more adaptive and learning-based data hiding solutions. Trend analysis of biomedical signal usage reveals that ECG is the most extensively investigated signal, followed by EEG, PPG, and EMG, suggesting a clear research growth hierarchy across signal modalities. Evaluation practices are primarily centered on imperceptibility, robustness, and capacity, which are most frequently assessed using Percentage Root-mean-square Difference (PRD), Bit Error Rate (BER), and payload-related metrics. Furthermore, security enhancement strategies integrating cryptographic techniques and blockchain-based frameworks are identified as promising directions for strengthening the protection of Patient Health Records (PHR). By consolidating existing taxonomies, trend findings, and evaluation strategies, this review highlights key research gaps, particularly the under exploration of non-ECG signal modalities and the limited adoption of intelligent methods, and provides a structured foundation to guide future developments in biomedical signal data hiding.

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Keywords : Biomedical signal, Medical patient record, Patient health record, Cybersecurity, Information hiding, Information security, ICT infrastructure


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© 2026  The Author(s). Pubblicato da Elsevier Masson SAS. Tutti i diritti riservati.
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Vol 6 - N° 4

Articolo 100292- dicembre 2026 Ritorno al numero
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