How does human odorant binding protein bind odorants? The case of aldehydes studied by molecular dynamics - 09/07/09
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Abstract |
Human Odorant Binding Protein (OBPIIa) has a strong affinity for odorants belonging to the family of aldehydes. After having built the initial structures based on the protein sequence, we have performed molecular dynamics simulations on human OBP, free and bound to citral and undecanal to examine the reasons for this affinity from a dynamic point of view. The formation of a Schiff base between a Lysine residue and the aldehyde function could be responsible for this strong affinity.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Human odorant binding protein, Citral, Undecanal
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Vol 12 - N° 8
P. 905-910 - agosto 2009 Ritorno al numero
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