Antidepressants are the most commonly prescribed class of medications in the United States. The clinician should be mindful of the many antidepressants that can produce seizures following an accidental exposure or an overdose. A broader understanding of the seizure potential of antidepressants, combined with the ability to recognize individuals at risk for a seizure after an overdose, can aid clinicians in determining the need for inpatient monitoring, and help facilitate their treatment decisions.