Multiple sclerosis is a chronic, disabling disease frequently striking young adults. Caring for a patient with this uncertain and progressive disease requires a comprehensive and multidisciplinary approach. Many patients with multiple sclerosis will have near normal lifespan, therefore it is vital that the health care professional be aware of the potential complications that these patients face from their disease and from the aging process. Understanding the challenges faced by an aging patient with multiple sclerosis can help the health care professional minimize morbidity and disability.