Aggressive subcutaneous panniculitis-like T-cell lymphoma with hemophagocytosis in two children (subcutaneous panniculitis-like T-cell lymphoma) - 07/08/11
, Sapna P. Sadarangani, MD b, Yuin-Chew Chan, MD c, Mei-Yoke Chan, MD b, Ah-Moy Tan, MD b, Suat-Hoon Tan, MD c, Yong-Kwang Tay, MD a, Siok-Bian Ng, MD d
Reprint requests: Mark Jean-Aan Koh, MD, Department of Dermatology, Changi General Hospital, 2 Simei Street 3, Singapore 529889.Abstract |
Subcutaneous panniculitis-like T-cell lymphoma is an uncommon form of cutaneous lymphoma in the pediatric population. It is characterized histologically by subcutaneous infiltration of pleomorphic cytotoxic T cells, mimicking a lobular panniculitis. Although usually described as having an indolent clinical course, the condition may be complicated by systemic involvement and hemophagocytic syndrome, resulting in a poorer prognosis. We present two pediatric patients with aggressive forms of subcutaneous panniculitis-like T-cell lymphoma complicated by hemophagocytic syndrome, and discuss the current literature.
Il testo completo di questo articolo è disponibile in PDF.Key words : ⍺/β, T cells, chemotherapy, cytophagic histiocytic panniculitis, hemophagocytic syndrome, subcutaneous panniculitis-like T-cell lymphoma
Abbreviations used : CHOP, CHP, SPTCL
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| Funding sources: None. |
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| Conflicts of interest: None declared. |
Vol 61 - N° 5
P. 875-881 - novembre 2009 Ritorno al numero
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