A single-center, dose-comparison, pilot study of botulinum neurotoxin type A in female patients with upper facial rhytids: Safety and efficacy - 08/08/11
, Jean Carruthers, MD b
Reprint requests: Alastair Carruthers, MD, Departments of Dermatology and Skin Science, University of British Columbia, 943 W Broadway, Suite 820, Vancouver, British Columbia V5Z 4E1, Canada.Abstract |
Background |
Treating multiple upper facial rhytids at one time is common, but has not been researched extensively.
Objective |
We sought to compare the safety, efficacy, and effect duration of 3 botulinum neurotoxin type A (BoNTA) doses in treating multiple upper facial rhytids.
Method |
Sixty women, randomized to 32, 64, or 96 U total doses, were assessed at baseline, week 2, week 4, then every 4 weeks. The primary efficacy measure was proportion of responders on the patient global assessment of improvement. Adverse events (AEs) were monitored.
Results |
All BoNTA doses were effective and safe. Significant between-group differences occurred in the percentage of responders (96 U: 71%, 64 U: 61%, 32 U: 26%; P = .0007). Adverse events did not differ significantly among groups; no serious treatment-related adverse events occurred.
Limitations |
BoNTA doses were fixed and not tailored to individuals.
Conclusion |
These results confirm the efficacy and safety of 3 doses of BoNTA for treating upper facial rhytids in female patients; higher doses afforded greater benefit.
Il testo completo di questo articolo è disponibile in PDF.Abbreviations used : AE, BoNTA, FWS, PGA, TOGA
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| Supported by a grant from Allergan Inc, Irvine, California. |
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| Disclosure: Drs Carruthers and Carruthers are consultants and investigators for and receive honoraria from Allergan Inc, which sponsored the study and the preparation of the article. They are also consultants and investigators for Merz GmbH and Solstice Neurosciences Inc. |
Vol 60 - N° 6
P. 972-979 - giugno 2009 Ritorno al numero
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