Neuroselective transcutaneous electrical stimulation reveals neuronal sensitization in atopic dermatitis - 08/08/11
Reprint requests: Setsuya Aiba, MD, PhD, Department of Dermatology, Tohoku University Graduate School of Medicine, Seiryo-machi, Aoba-ku, Sendai 980-8574, Japan.Abstract |
Background |
The neuroselective transcutaneous electrical stimulator (NTES) can provoke itch and/or pain by the application of a 5-Hz alternating current.
Objective |
We sought to examine whether there is any difference in the perception of the stimulus evoked by the NTES between patients with atopic dermatitis (AD) and healthy control subjects.
Methods |
In all, 24 healthy control subjects and 24 patients with AD (nonlesional skin) were stimulated on 7 body sites using the NTES. Qualitative differences in the evoked perceptions and quantitative differences in the current intensity required to evoke perception were statistically analyzed.
Results |
The NTES preferentially evoked itch in patients with AD. The current perception threshold was statistically lower in AD than in healthy control subjects on 3 body sites.
Limitations |
Tests were performed on limited body areas.
Conclusion |
We demonstrated that the NTES can reveal neuronal sensitization to itch in nonlesional atopic skin.
Il testo completo di questo articolo è disponibile in PDF.Abbreviations used : AD, CPT, HC, MIT, MPT, NTES
Mappa
| Supported in part by the 21st Center of Excellence program of Tohoku University and by New Energy and Industrial Technology Development Organization. |
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| Conflicts of interest: None declared. |
Vol 60 - N° 4
P. 609-614 - aprile 2009 Ritorno al numero
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