Topical combination therapy for cutaneous squamous cell carcinoma in situ with 5-fluorouracil cream and imiquimod cream in patients who have failed topical monotherapy - 09/08/11
Reprint requests: Andrew L. Ondo, MD, 4351 E Lohman Ave, Suite 208, Las Cruces, NM 88011.Las Cruces, New Mexico; Boise, Idaho; Brunswick, Ohio; and New York, New York
Abstract |
Topical therapeutic options for cutaneous squamous cell carcinoma in situ include 5-fluorouracil cream and imiquimod cream. Such treatment may be preferable to surgical or destructive modalities in certain anatomic locations and in instances where patients are unwilling or poor surgical candidates. We present 4 such patients with cutaneous squamous cell carcinoma in situ involving a digit. Each patient failed treatment with imiquimod cream as monotherapy. In addition, two patients failed treatment with 5-fluorouracil cream as monotherapy. All 4 responded completely to 5-fluorouracil and imiquimod cream as combination therapy. In patients who have failed monotherapy with a topical agent for cutaneous squamous cell carcinoma in situ, combination treatment using both topical 5-fluorouracil cream and imiquimod cream may be considered as an alternative therapeutic strategy.
Il testo completo di questo articolo è disponibile in PDF.Abbreviations used : IFN, IL, SCC, TLR
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| Funding sources: None. Disclosure: Dr Mings is a speaker for 3M, the manufacturer of imiquimod. |
Vol 55 - N° 6
P. 1092-1094 - dicembre 2006 Ritorno al numero
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