Primary cutaneous signet ring cell carcinoma expressing cytokeratin 20 immunoreactivity - 09/08/11
, Masanobu Kumakiri, MD a, Sachio Kouraba, MD a, Atsushi Tokuriki, MD a, Shinichi Ansai, MD b
Reprint requests: Takahiro Kiyohara, MD, Department of Dermatology, University of Fukui, 23-3 Shimoaizuki, Matsuoka-cho, Yoshida-gun, Fukui 910-1193, Japan.Fukui and Sapporo, Japan
Abstract |
Primary cutaneous signet ring cell carcinoma (PCSRCC) is a very unusual but distinctive clinicopathologic entity that can simulate metastatic adenocarcinomas. It is defined as a diffuse malignant epithelial neoplasia localized in the dermis and subcutis without epidermal involvement, showing variable amounts of signet ring cells, without evidence of visceral adenocarcinoma. We present 2 cases of PCSRCC, which involved eyelids and axilla respectively. Despite thorough systemic workup, primary sources could not be demonstrated in either case. The tumor cells are positive for gross cystic disease fluid protein 15 in addition to a variety of glandular markers. Furthermore, both cases were immunostained with cytokeratin 20 (CK20). In conclusion, we report 2 cases of PCSRCC expressing CK20 immunoreactivity. CK20-positive primary cutaneous tumors should include PCSRCC in addition to Merkel cell carcinoma.
Il testo completo di questo articolo è disponibile in PDF.Mappa
| Funding sources: None. Conflicts of interest: None identified. |
Vol 54 - N° 3
P. 532-536 - marzo 2006 Ritorno al numero
Articolo precedente
- Butorphanol for treatment of intractable pruritus
- Aerlyn G. Dawn, Gil Yosipovitch
- Perineal ulcers in an infant: An unusual presentation of postnatal cytomegalovirus infection
- John G. Hancox, Avinash K. Shetty, Omar P. Sangueza, Gil Yosipovitch
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?