A randomized, double-blind, placebo-controlled trial of photopheresis in systemic sclerosis - 09/08/11
, Lars E. French b, Youn Kim, MD c, Emil Bisaccia, MD d, Winfried Graninger, MD e, Hesam Nahavandi, MD a, Frank J. Strobl, MD, PhD f, Edward Keystone, MD g, Marilyn Mehlmauer, MD h, Alain H. Rook, MD i, Irwin Braverman, MD jin the name of the Systemic Sclerosis Study Group
Reprint requests: Robert Knobler, MD, Division of Special & Environmental Dermatology, Department of Dermatology, Medical University of Vienna, Waehringer Guertel 18-20, A-1090 Vienna, Austria.Vienna and Graz, Austria; Geneva, Switzerland; Stanford and Pasadena, California; New Haven, Connecticut; Morristown, New Jersey; Exton and Philadelphia, Pennsylvania; and Toronto, Ontario, Canada
Abstract |
Background |
Systemic sclerosis is a multisystemic connective tissue disease with marked involvement of the skin and joints for which few effective evidence based therapies are available. To further investigate the efficacy of extracorporeal photochemotherapy on early aggresive cutaneous disease, a randomized, double-blind, placebo-controlled trial was performed.
Objective |
Our aim was to evaluate the efficacy of photopheresis in the treatment of patients with systemic sclerosis (scleroderma).
Methods |
This randomized, double-blind, placebo-controlled clinical trial was conducted at 16 investigational sites in the United States, Canada, and Europe. Sixty-four patients with typical clinical and histologic findings of scleroderma, of less than 2 years’ duration, were studied. Patients did not receive any other concomitant treatment for scleroderma. Patients were randomized to receive either active or sham photopheresis treatment on two consecutive days monthly for 12 months. Severity of skin (skin scores assessed in 22 body regions) and joint involvement (60 joints examined for contractures) were assessed on a monthly basis.
Results |
A statistically significant improvement in skin scores as compared with baseline was observed at 6 months (P = .0024) and 12 months (P = .008) among those who received active photopheresis, but not among those who received sham photopheresis. Comparison of skin scores between the two study arms did not achieve statistical significance because of the small sample size of the study arms. Joint involvement was also significantly improved after 6 months (P = .002) and 12 months (P = .001) of active photopheresis when compared with baseline.
Limitations |
The study lacks sufficient statistical power to reveal a significant difference in skin and joint manifestations between the active and sham photopheresis arms.
Conclusion |
Photopheresis induced significant improvement of skin and joint involvement in patients with scleroderma of recent onset; however, any effect when compared with sham treatment and a possible placebo effect may be modest.
Il testo completo di questo articolo è disponibile in PDF.Mappa
| Funding sources: Therakos, Inc. Disclosure: Drs Knobler and Bisaccia are consultants for Therakos; Dr Strobl is an employee of Therakos, Inc. |
Vol 54 - N° 5
P. 793-799 - maggio 2006 Ritorno al numero
Articolo precedente
- Eczema herpeticum patients needed for referral
- Fibrous hamartoma of infancy: An Italian multi-institutional experience
- Elena Carretto, Patrizia Dall’Igna, Rita Alaggio, Fortunato Siracusa, Claudio Granata, Andrea Ferrari, Giovanni Cecchetto
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?