Long-term Mortality After Primary Percutaneous Coronary Intervention for High-risk Myocardial Infarction - 11/08/11
, Gerry P. Devlin, MD b, Gaelle Dutu c, Steve Holmes b, Christopher M. Nunn, FRACP bRiassunto |
Background |
Primary percutaneous coronary intervention (PPCI) has evolved, including the introduction of stents and platelet glycoprotein IIb/IIIa receptor inhibitors (GPI). The effects of these changes and other variables on long-term survival for a single-centre service were studied.
Methods |
A prospective database of clinical and angiographic variables were kept for patients treated with PPCI in Waikato Hospital from 1996 to 2006 (n=527). This was analysed with long-term mortality data. Survival was recorded using Kaplan–Meier curves. Multivariate analysis of factors at presentation, including ethnicity was performed.
Results |
5, 8 & 10-year survival rates were 76.5% (n=274), 72.7% (n=125) & 71.0% (n=19) respectively. Increased stent (42.8% vs. 84.1%, p<0.001) and GPI (39.6% vs. 73.3%, p<0.001) use was seen between early and late stages of the study. Stent use was associated with greater 5-year survival (80.5% vs. 70.8%, p=0.02), but GPI use was not. Multivariate analysis showed stent use independently predicted reduced mortality. Age, Maori ethnicity, renal failure and cardiogenic shock predicted higher mortality.
Conclusions |
Survival after PPCI remains high long-term. Stent and GPI use significantly increased. Stent, but not GPI, use was associated with improved survival. Maori ethnicity was under-represented in the study and is associated with worse long-term outcomes after myocardial infarction (MI).
Il testo completo di questo articolo è disponibile in PDF.Keywords : Angioplasty, Myocardial infarction, Survival, Maori
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Vol 19 - N° 1
P. 19-25 - gennaio 2010 Ritorno al numeroBenvenuto su EM|consulte, il riferimento dei professionisti della salute.
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