Change in pulse wave velocity throughout normal pregnancy and its value in predicting pregnancy-induced hypertension: A longitudinal study - 18/08/11
, Kazuhiro Takahashi, MD, PhD, Sachiko Suzuki, Noriko Henmi, MD, Yukio Yokoyama, MD, PhD, Hirohisa Kurachi, MD, PhD
Reprint requests: Dr Masahide Ohmichi, Department of Obstetrics and Gynecology, Yamagata University School of Medicine, 2-2-2, Iidanishi, Yamagata, Yamagata, 990-9585, Japan.Abstract |
Objective |
We longitudinally examined the changes of brachial to ankle distensibility using pulse wave velocity (PWV) throughout pregnancy and its difference between normal pregnancy and pregnancy-induced hypertension (PIH) groups.
Study design |
One hundred and eighty-three pregnant women were included in this study. The PWV examinations were performed in a longitudinal way during the first, second, and third trimesters of pregnancy, and immediately and 1 month after delivery.
Results |
In normal pregnancies, the PWV significantly decreased at the second trimester, increased from the third trimester through immediately after delivery, and decreased again at 1 month after delivery. In PIH patients, it increased in proportion to the progression of gestation.
Conclusion |
We monitored the longitudinal changes in PWV and constructed a PWV normogram during pregnancy. The predictive value of PWV and blood pressure for PIH was higher than that of blood pressure alone, suggesting the usefulness of measuring PWV to predict PIH.
Il testo completo di questo articolo è disponibile in PDF.Key words : PWV, Arterial stiffness, Pregnancy, Pregnancy-induced hypertension
Mappa
| Supported in part by a Grant-in-Aid for Exploratory Research, No. 16659444 (H.K.), and for Young Scientists, No. 16790936 (A.M.-A.) from the Ministry of Education, Culture, Sports, Science and Technology of Japan, and in part by a Grant-in-Aid for Scientific Research, No. 16591636 (K.T.), and for the 21st century Center of Excellence (COE) Program from the Japan Society for the Promotion of Science, and in part by a Grant-in-Aid for Research on Health Sciences focusing on Drug Innovation from the Japan Health Sciences Foundation. |
Vol 195 - N° 2
P. 464-469 - agosto 2006 Ritorno al numero
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