Mast cell distribution, activation, and phenotype in xanthoma - 19/08/11
, Sawa Kunimitsu, AD a, Kana Wada, AD a, Mitsunori Ikeda, MD, PhD a, Akira Keyama, MD, PhD b, Hajime Kodama, MD, PhD a
Reprint requests: Masaaki Matsumoto, MD, PhD, Department of Dermatology, Kochi Medical School, Okohcho, Nankoku, Kochi 783-8505, Japan.Kochi, Japan
Abstract |
Background |
Activated mast cells enhance the uptake of mast cell–derived proteoglycan–low-density lipoprotein complexes by macrophages.
Objective |
We sought to investigate mast cell contribution to the pathogenesis of xanthoma.
Methods |
Twenty cases of xanthelasma palpebrarum and 6 cases of tuberous xanthoma lesions were analyzed using immunohistochemical staining.
Results |
Xanthelasma lesions contained up to 5-fold more tryptase-stained mast cells than tuberous xanthoma lesions. Tuberous xanthoma lesions especially showed extensive staining of tryptase around mast cells and within some macrophages and foam cells. More than 99% of mast cells in xanthelasma lesions contained both tryptase and chymase. Approximately 60% of mast cells represented only tryptase in tuberous xanthoma lesions where the ratio of macrophages to tryptase-stained mast cells was extremely high (15:1) as compared with xanthelasma lesions (2:1).
Limitations |
A change in mast cell phenotype has not been necessarily proven.
Conclusion |
Mast cells are activated under the microenvironment in which macrophages predominate rather than mast cells, which thus reflects the clinical phenotypes of xanthoma lesions.
Il testo completo di questo articolo è disponibile in PDF.Abbreviations used : LDL, MCC, MCT, MCTC
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| Funding sources: None. Conflicts of interest: None declared. |
Vol 56 - N° 6
P. 1006-1012 - giugno 2007 Ritorno al numero
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