Biofeedback is a clinical modality in which technology or instrumentation is used to allow a patient to gain awareness of, and control over, physiologic processes. Successful treatment employing biofeedback can be beneficial for several stress-related and pain conditions, as well as other forms of somatic disturbance. Collectively, the same conditions that may respond to biofeedback are those often seen in a primary care practice and are conditions that can result in chronic dysfunction and disability. Understanding the forms and uses of biofeedback, the research evidence base, and practical referral guidelines can help the family physician to offer recommendations and referrals to patients.