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Association between lipid testing and statin therapy in acute myocardial infarction patients - 21/08/11

Doi : 10.1016/j.ahj.2004.09.057 
Dennis T. Ko, MD a, b, d, , David A. Alter, MD, PhD a, b, d, Alice M. Newman, MSc d, Linda R. Donovan, BScN, MBA d, Jack V. Tu, MD, PhD c, d
a Division of Cardiology, Schulich Heart Centre, Toronto, Ontario, Canada 
b Department of Medicine, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada 
c Division of General Internal Medicine and Clinical Epidemiology and Health Care Research Program, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada 
d Institute for Clinical Evaluative Sciences, University of Toronto, Toronto, Ontario, Canada 

Reprint requests: Dennis T. Ko, MD, Institute for Clinical Evaluative Sciences, University of Toronto, G-106, 2075 Bayview Avenue, Toronto, Ontario, Canada M4N 3M5.

Riassunto

Background

Clinical guidelines recommend lipid testing in all hospitalized acute myocardial infarction (AMI) patients. Inhospital lipid testing has also been proposed as a quality indicator for AMI care, but little is known about its use or importance. We sought to examine rates of inhospital lipid testing and its association with statin therapy at hospital discharge.

Methods

We performed an analysis using medical chart abstraction data that included demographic and comprehensive clinical information for patients hospitalized in Ontario, Canada, with an AMI from 1999 to 2001.

Results

Among 11468 patients, inhospital lipid testing was performed in 6019 (52.5%) patients and in 4169 (36.4%) patients within 24 hours of admission. Patients who had lipid testing were significantly more likely to be discharged on statin therapy compared with patients not tested (41.4% vs 23.0%, P < .001). In addition, inhospital lipid testing was strongly associated (odds ratio 3.61, 95% CI 3.15-4.14) with statin therapy prescription at hospital discharge after adjusting for other clinical, physician, and hospital factors.

Conclusions

Despite endorsements from practice guidelines, less than half of all admitted AMI patients received lipid testing within 24 hours of hospital admission. Because inhospital lipid testing was strongly associated with the initiation of statin therapy at discharge, many opportunities to initiate statin therapy were lost. Efforts to increase the use of lipid testing in hospitalized AMI patients may translate into higher rates of lipid-lowering therapy and improved patient outcomes.

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 The results and conclusions of this study are those of the authors and should not be attributed to any of the sponsoring agencies.


© 2005  Mosby, Inc. Tutti i diritti riservati.
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Vol 150 - N° 3

P. 419-425 - settembre 2005 Ritorno al numero
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