The metastatic lymph node ratio predicts survival in colon cancer - 21/08/11
, Jason Fleming, M.D. b, Thomas Anthony, M.D. a
Corresponding author. Tel.: +1-214-648-9459; fax: +1-214-648-7965.Abstract |
Background |
Lymph node metastases are the most important predictor of survival in non–stage IV colon cancer. Recent studies of gastric cancer have shown a prognostic significance of a lymph node ratio (number of positive nodes divided by total number harvested). Our goal was to determine whether a lymph node ratio (LNR) would predict disease-free survival (DFS) and overall survival (OS) in a tertiary care Veterans Affairs medical center.
Methods |
A retrospective review of a prospectively collected database of colon cancer patients was performed to determine the effect of LNR on DFS and OS. A cohort of 232 patients with non–stage IV colon cancer was eligible for analysis. Survival curves were constructed using the Kaplan-Meier method.
Results |
For all patients, a LNR of .08 was identified as a breakpoint for predicting OS and DFS. Specific analysis of stage III patients revealed that a LNR of .18 was predictive of DFS.
Conclusions |
This study showed the prognostic significance of ratio-based staging for colon cancer and may aid in future staging systems.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Colon cancer, Lymph node ratio, Prognosis, Survival
Mappa
| P.S. and S.D. contributed equally to this work. |
Vol 194 - N° 6
P. 827-832 - dicembre 2007 Ritorno al numero
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