Apolipoprotein E Polymorphisms in Patients With Primary Open-Angle Glaucoma - 21/08/11
, Gunnar Tasa c, Mona Seibt Palmér d, Erkki Juronen c, Pait Teesalu e, Kaj Blennow d, f, Henrik Zetterberg d, f
Inquiries to Madeleine Zetterberg, Institute of Neuroscience and Physiology, Department of Clinical Neuroscience and Rehabilitation, Section of Ophthalmology, Sahlgrenska Academy at Göteborg University, Sahlgrenska University Hospital/Mölndal, 431 80 Mölndal, SwedenRiassunto |
Purpose |
To investigate apolipoprotein E (APOE) polymorphisms, which are known to influence the risk of Alzheimer disease (AD), in patients with primary open-angle glaucoma (POAG).
Design |
Retrospective case-control association study.
Methods |
Patients with POAG (n = 242) and controls (n = 187) were analyzed for the APOE ϵ2/ϵ3/ϵ4 polymorphisms using minisequencing technique.
Results |
The Alzheimer-associated APOE ϵ4 allele had similar frequencies in the POAG group and in the control group. There was no difference between cases and controls with regard to APOE genotypes.
Conclusions |
If a common pathogenic mechanism exists for the two age-related neurodegenerative diseases, POAG and AD, it does not involve APOE polymorphisms.
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Vol 143 - N° 6
P. 1059-1060 - giugno 2007 Ritorno al numero
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