A randomized, double-blind, placebo-controlled trial of the combined effect of doxycycline hyclate 20-mg tablets and metronidazole 0.75% topical lotion in the treatment of rosacea - 21/08/11
, Aida Lugo Somolinos, MD a, Pablo I. Almodóvar, MD a, Guy Webster, MD b, Mark Bradshaw, PhD c, Christopher Powala, BS d
Reprint requests: Jorge Sanchez, MD, Department of Dermatology, Puerto Rico Medical Center, Medical Sciences Campus, Pharmacy Building, 5th Floor, Rio Piedras, PR 00935.Rio Piedras, Puerto Rico; Philadelphia, Pennsylvania; Princeton, New Jersey; and Newton, Pennsylvania
Abstract |
Background |
Subantimicrobial doses of doxycycline may improve outcomes in rosacea when combined with topical metronidazole and used as maintenance monotherapy.
Objective |
The purpose of this study was to evaluate the safety and efficacy of doxycycline hyclate 20 mg (subantimicrobial dose doxycycline) administered twice daily as an adjunct to metronidazole 0.75% topical lotion in the treatment of rosacea.
Methods |
Patients received subantimicrobial doses of doxycycline twice daily plus metronidazole (n = 20) or placebo plus metronidazole (n = 20) for 12 weeks. Subantimicrobial-dose doxycycline or placebo monotherapy continued for 4 weeks. The primary efficacy measure was change from baseline in total inflammatory lesions at weeks 2 and 16.
Results |
Total inflammatory lesions were reduced significantly (P =.048) by week 4 and by all subsequent visits in the subantimicrobial-dose doxycycline/metronidazole group compared with placebo/metronidazole. Changes from baseline increased over time and were maintained during subantimicrobial-dose doxycycline monotherapy.
Conclusion |
Adjunctive use of subantimicrobial dose doxycycline significantly reduced the clinical signs of rosacea compared with metronidazole alone and may be useful maintenance monotherapy.
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| Supported by CollaGenex Pharmaceuticals, Inc. Conflicts of interest: None identified. |
Vol 53 - N° 5
P. 791-797 - novembre 2005 Ritorno al numero
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
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