Trimodal imaging endoscopy may improve diagnostic accuracy of early gastric neoplasia: a feasibility study - 23/08/11
Reprint requests: Mitsuru Kaise, MD, Department of Endoscopy, Jikei University School of Medicine, 3-25-8 Nishishinbashi, Minato-ku, Tokyo 105-8461, Japan.Tokyo, Japan
Abstract |
Background |
A considerable number of superficial gastric neoplasias are overlooked with conventional white light imaging (WLI) endoscopy.
Objective |
The aim was to investigate the diagnostic potential of trimodal imaging endoscopy (TME), which combines WLI, autofluorescence imaging (AFI), and narrow-band imaging (NBI), for superficial gastric neoplasia.
Design |
Feasibility study.
Setting |
Single academic center.
Patients |
Sixty-two patients with or without gastric neoplasia.
Intervention |
Each patient serially assessed with WLI, AFI, and magnifying endoscopy with NBI (ME-NBI) by an endoscopist blinded for clinical information. ME-NBI over WLI and AFI was designated as TME. Histopathology of biopsy and ESD specimens was evaluated and used as the gold standard.
Main Outcome Measurements |
Sensitivity and specificity of endoscopic diagnosis of pathology-proven neoplasia by per-patient and per-lesion analyses.
Results |
The study included 47 pathology-proven neoplasias and 44 pathology-proven nonneoplasias that were detected as neoplasias with any of the modalities. By a per-lesion analysis, the sensitivity of TME (89.4%) was higher than that of WLI (76.6%) and AFI (68.1%). The specificity of TME (98.0%) was higher than that of WLI (84.3%) and AFI (23.5%). By a per-patient analysis, the sensitivity of TME (90.9%) was higher than that of WLI (75%) and AFI (68.2%). The specificity of TME (100%) was higher than that of WLI (72.2%) and AFI (44.4%).
Limitations |
Case-enriched population at a single center.
Conclusions |
Higher diagnostic accuracy of TME over conventional WLI indicates the feasibility of TME for the efficacious diagnosis of early gastric neoplasia.
Il testo completo di questo articolo è disponibile in PDF.Abbreviations : AFE, AFI, BE, CI, ESD, FMS, ME-NBI, NBI, path-neoplasia, TME, WLI
Mappa
| DISCLOSURE: All authors disclosed no financial relationships relevant to this publication. |
|
| If you would like to chat with an author of this article, you may contact him at masa-kato@jikei.ac.jp. |
Vol 70 - N° 5
P. 899-906 - novembre 2009 Ritorno al numero
Articolo precedente
- EUS in pediatric patients
- Tan Attila, Douglas G. Adler, Kristen Hilden, Douglas O. Faigel
- EUS-FNA predicts 5-year survival in pancreatic endocrine tumors
- Fátima A.F. Figueiredo, Marc Giovannini, Genevieve Monges, Erwan Bories, Christian Pesenti, Fabrice Caillol, Jean Robert Delpero
Benvenuto su EM|consulte, il riferimento dei professionisti della salute.
L'accesso al testo integrale di questo articolo richiede un abbonamento.
Già abbonato a @@106933@@ rivista ?