Leukemic cell infiltration into the large intestine in a patient with acute myelogenous leukemia - 23/08/11
Doi : 10.1016/j.gie.2007.08.051
| Commentary Leukemic involvement of the colon can present with abdominal pain, bleeding, diarrhea, or obstruction. Its manifestations encompass polypoid lesions with or without intussusception, rectal watermelon vasculopathy, and colitis. This patient again reminds us that disease manifests in but a limited number of ways and that all aphthae are not Crohn’s disease or manifestations of infection. Biopsy specimens should be obtained on all abnormal-appearing and sometimes normal-appearing tissue for histologic confirmation of suspected pathology. To our list of potential causes of colonic aphthae (Greek: ulceration) we now can add leukemia. When patients with AML, especially the FAB subtype of M4 or M5, develop GI symptoms such as hematochezia or diarrhea, extramedullary disease of AML with GI involvement should be considered; monocytic leukemias (M4, M5) are more likely than other leukemias to present with extramedullary disease. Lawrence J. Brandt, MD Associate Editor for Focal Points |
© 2008
American Society for Gastrointestinal Endoscopy. Pubblicato da Elsevier Masson SAS. Tutti i diritti riservati.
Vol 67 - N° 2
P. 353-354 - febbraio 2008 Ritorno al numero
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