Association between hyperhomocysteinemia and primary pulmonary hypertension - 26/08/11
, Sunder Sandur a, Donald W. Jacobsen b, Sanjiv Tewari a, Masroor Mustafa d, Edward J. Mascha c, Killian Robinson eAbstract |
Study objective: This case-control study was conducted to test the hypothesis that fasting homocysteine levels are higher in PPH patients than in healthy controls. Design: Levels of plasma total homocysteine, serum folate, vitamin B-12, and serum creatinine in 18 consecutive patients with PPH were compared with data from 36 age- and sex-matched controls. Results: Eight of the 18 patients (44.4%) and three of the 36 controls (8.3%) had elevated plasma total homocysteine (tHcy) levels (⩾15μmol/l, odds ratio 8.8; 95% CI: 2.0–39.6; P=0.005). There was an inverse correlation between tHcy levels and creatinine clearance in patients with PPH (P=0.036). Conclusion: PPH patients are significantly more likely to have hyperhomocysteinemia, and higher mean plasma total homocysteine levels than in controls. Plasma total homocysteine may be an important factor in the pathogenesis of PPH.
Il testo completo di questo articolo è disponibile in PDF.Keywords : Hyperhomocysteinemia, Primary pulmonary hypertension
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Vol 97 - N° 7
P. 825-829 - luglio 2003 Ritorno al numero
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