Background: Recombinant human platelet derived growth factor-BB gel (PDGF gel) has been shown to be effective in the treatment of diabetic neuropathic ulcers. It is also being used off-label to speed wound healing of flaps, grafts, and wounds from Mohs micrographic surgery. Objective: The purpose of the study was to compare the rate of healing in wounds treated with PDGF gel and with wounds treated with conventional therapy (antibiotic ointment). Methods: A double-blind controlled study of 7 healthy volunteers was performed. With a 4-mm skin punch biopsy instrument, two full-thickness wounds were made on each arm of each volunteer. Fourteen wounds treated with PDGF gel were compared with 14 wounds treated with antibiotic ointment. Healing was evaluated by visual determination of the global percentage healed and wound depth. Results: Wounds treated with PDGF gel showed a significantly faster rate of healing on each of the initial 6 follow-up visits. The greatest difference was on day 10 when PDGF-treated wounds were 71% healed compared with 28% for antibiotic-treated wounds (P = .0005). At days 22 and 24, 92.9% and 100% of the PDGF gel-treated wounds were healed, compared with 50% and 57%, respectively (P = .0313 and P = .0313), in the antibiotic ointment group. By day 29, both PDGF gel and antibiotic-treated wounds were healed. PDGF also decreased wound depth compared with wounds treated with antibiotic ointment at days 8 and 10 with P values <.0313 and <.0020, respectively. Conclusion: We conclude that PDGF gel speeds healing of acute full-thickness wounds compared with antibiotic ointment. (J Am Acad Dermatol 2001;45:857-62.)