As a method for detection of allergen specific immunoglobulin E (IgE), skin testing has been in routine clinical use for nearly 100 years. During this time, various methods and devices have been used, and no one method or device has emerged as a standard. Devices for skin testing were discussed in the article by Oppenheimer elsewhere in this issue. This article reviews techniques appropriate for use in clinical practice, focusing on advantages and limitations. Techniques for research applications are described in detail in the article by Dreborg. For the purpose of study, skin test methods can be described as epicutaneous (or percutaneous) or intradermal (or intracutaneous).