Oxidants and Antioxidant Therapy - 03/09/11
Doi : 10.1016/S0749-0704(05)70162-7
Riassunto |
Oxygen free-radicals and other toxic metabolites of oxygen have been implicated in a number of disease processes. In this article, three objectives are addressed:
1 | To review the rationale for antioxidant therapy in organ injury after sepsis and other inflammatory states; |
2 | To overview the experimental data suggesting potential efficacy for antioxidant therapy; |
3 | To review clinical data regarding the use of antioxidants in preventing or minimizing organ injury. |
Mappa
| Address reprint requests to Ori D. Rotstein, MD, Toronto General Hospital, 200 Elizabeth Street, EN 9-232, Toronto, Ontario Canada, M5G 2C4. e-mail: ori.rotstein@uhn.on.ca The data presented from the author's laboratory was supported by the Medical Research Council of Canada and the Defense and Civil Institute for Environmetnal Medicine. |
© 2001
W. B. Saunders Company. Pubblicato da Elsevier Masson SAS. Tutti i diritti riservati.
Vol 17 - N° 1
P. 239-247 - gennaio 2001 Ritorno al numero
Articolo precedente
- Cytopathic Hypoxia : Mitochondrial Dysfunction as Mechanism Contributing to Organ Dysfunction in Sepsis
- Mitchell P. Fink
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