KIT SIGNAL TRANSDUCTION - 04/09/11

Doi : 10.1016/S0889-8588(05)70294-X

Marcia L. Taylor, PhD ^{^{*
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland}}, Dean D. Metcalfe, MD ^{^{*
Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland}}

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BACKGROUND

STRUCTURE OF KIT

THE KIT LIGAND, STEM CELL FACTOR

FUNCTIONS OF THE KIT/STEM CELL FACTOR INTERACTION

PATHWAYS INVOLVED IN KIT SIGNAL TRANSDUCTION

Overview of the kit Signaling Pathway

COMPONENTS OF THE KIT SIGNALING PATHWAY

Kinases

Phospholipase Cγ1

Adaptor Proteins

Negative Regulation of kit Signaling

EFFECT OF ACTIVATING MUTATIONS ON KIT SIGNALING

Known Activating Mutations of c- kit

Consequences of the Activating Mutations on kit Signaling

SUMMARY

Address reprint requests to: Marcia L. Taylor, PhD, Laboratory of Allergic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 10, Room 11C-207, 10 Center Drive, MSC 1881, Bethesda, MD 20892–1881

Esportazione

Vol 14 - N° 3

P. 517-535 - giugno 2000 Ritorno al numero

Articolo precedente

REGULATION OF MAST CELL NUMBER AND FUNCTION
Arnold Kirshenbaum

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MASTOCYTOSIS AND THE SKIN
Nicholas A. Soter

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KIT SIGNAL TRANSDUCTION - 04/09/11

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